C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired box 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000075891 PAX2 9606 + 10:100735603-100829941 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355243 PAX2-001 100745711-100829941 protein_coding
  ENST00000361791 PAX2-006 100746220-100829589 protein_coding
  ENST00000370296 PAX2-002 100745711-100829941 protein_coding
  ENST00000427256 PAX2-003 100746228-100786970 protein_coding
  ENST00000428433 PAX2-201 100745711-100829941 protein_coding
  ENST00000483202 PAX2-004 100746264-100749916 retained_intron
  ENST00000553492 PAX2-008 100735603-100806599 processed_transcript
  ENST00000554172 PAX2-005 100748850-100824654 protein_coding
  ENST00000554363 PAX2-007 100746179-100809184 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastKidneyLiverLungOvaryPlacentaTestisENST00000355243ENST00000361791ENST00000427256ENST00000483202ENST00000553492ENST00000554172
Transcript ID Adrenal Bladder Brain Breast Kidney Liver Lung Ovary Placenta Testis
ENST00000355243 N/A N/A N/A N/A 5.431±0.00 N/A N/A N/A N/A N/A
ENST00000361791 0.019±0.00 N/A 0.129±0.00 N/A 11.684±0.00 N/A 0.060±0.00 0.838±1.09 0.087±0.00 1.738±1.54
ENST00000427256 N/A N/A N/A 0.314±0.00 N/A N/A N/A N/A N/A 0.240±0.00
ENST00000483202 N/A N/A N/A N/A N/A 0.031±0.00 N/A N/A 0.048±0.00 2.858±0.00
ENST00000553492 N/A N/A N/A N/A N/A N/A N/A N/A 0.112±0.00 N/A
ENST00000554172 N/A 2.742±0.00 N/A N/A N/A 0.041±0.00 N/A 0.064±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QB CIL_0007QB_0001 VISTA 10:100185085-100786577
CIL_00082U CIL_00082U_0001 VISTA 10:100312457-100914449
CIL_00082V CIL_00082V_0001 VISTA 10:100315129-100915721
CIL_00093R CIL_00093R_0001 VISTA 10:100355158-100955821
CIL_00093O CIL_00093O_0001 VISTA 10:100359362-100959974
CIL_0008BC CIL_0008BC_0001 VISTA 10:100387324-100989228
CIL_0008BD CIL_0008BD_0001 VISTA 10:100486833-101088338
CIL_0007U1 CIL_0007U1_0001 VISTA 10:100491715-101092615
CIL_0005DR CIL_0005DR_0001 CGP 10:100529072-100829941
CIL_0007KC CIL_0007KC_0001 UCNEbase 10:100612932-100859321
CIL_0003MX CIL_0003MX_0001 CGP 10:100735603-100965136

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001655 ISS urogenital system development
GO:0001656 IEA metanephros development
GO:0001657 IEA ureteric bud development
GO:0001658 ISS branching involved in ureteric bud morphogenesis
GO:0001709 ISS cell fate determination
GO:0001822 IEA kidney development
GO:0001823 ISS mesonephros development
GO:0001843 ISS neural tube closure
GO:0002072 ISS optic cup morphogenesis involved in camera-type eye development
GO:0003337 ISS mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003406 ISS retinal pigment epithelium development
GO:0003677 ISS:IEA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005764 IEA lysosome
GO:0005815 IDA microtubule organizing center
GO:0006351 ISS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0007275 IEA multicellular organismal development
GO:0007409 TAS axonogenesis
GO:0007417 IEA central nervous system development
GO:0007501 ISS mesodermal cell fate specification
GO:0007568 IEA aging
GO:0007601 TAS visual perception
GO:0008284 IEA positive regulation of cell proliferation
GO:0010001 ISS glial cell differentiation
GO:0016175 ISS superoxide-generating NADPH oxidase activity
GO:0021554 ISS optic nerve development
GO:0021631 ISS optic nerve morphogenesis
GO:0021633 ISS optic nerve structural organization
GO:0021650 ISS vestibulocochlear nerve formation
GO:0031016 IEA pancreas development
GO:0031667 IEA response to nutrient levels
GO:0032993 ISS protein-DNA complex
GO:0034451 IDA centriolar satellite
GO:0035566 IMP regulation of metanephros size
GO:0035799 ISS ureter maturation
GO:0039003 ISS pronephric field specification
GO:0042472 ISS inner ear morphogenesis
GO:0042981 IEA regulation of apoptotic process
GO:0043010 ISS camera-type eye development
GO:0043066 IDA negative regulation of apoptotic process
GO:0043067 IEA regulation of programmed cell death
GO:0043069 ISS negative regulation of programmed cell death
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043234 ISS protein complex
GO:0043491 ISS protein kinase B signaling
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045918 IMP negative regulation of cytolysis
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048513 IEA organ development
GO:0048793 ISS pronephros development
GO:0048854 ISS brain morphogenesis
GO:0048863 ISS stem cell differentiation
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0055114 IEA oxidation-reduction process
GO:0060231 ISS mesenchymal to epithelial transition
GO:0061205 IEA paramesonephric duct development
GO:0061360 ISS optic chiasma development
GO:0070301 ISS cellular response to hydrogen peroxide
GO:0070742 IEA C2H2 zinc finger domain binding
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071300 ISS cellular response to retinoic acid
GO:0071333 ISS cellular response to glucose stimulus
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0072001 IEA renal system development
GO:0072075 ISS metanephric mesenchyme development
GO:0072108 ISS positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072162 ISS metanephric mesenchymal cell differentiation
GO:0072164 IEA mesonephric tubule development
GO:0072172 IEA mesonephric tubule formation
GO:0072177 IEA mesonephric duct development
GO:0072179 ISS nephric duct formation
GO:0072189 ISS ureter development
GO:0072197 IEA ureter morphogenesis
GO:0072205 ISS metanephric collecting duct development
GO:0072207 IEP metanephric epithelium development
GO:0072221 ISS metanephric distal convoluted tubule development
GO:0072289 ISS metanephric nephron tubule formation
GO:0072300 ISS positive regulation of metanephric glomerulus development
GO:0072305 ISS negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 ISS regulation of metanephric nephron tubule epithelial cell differentiation
GO:0072593 ISS reactive oxygen species metabolic process
GO:0090102 ISS cochlea development
GO:0090103 ISS cochlea morphogenesis
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 ISS negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 ISS negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 ISS negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process
GO:2000594 ISS positive regulation of metanephric DCT cell differentiation
GO:2000597 ISS positive regulation of optic nerve formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028148 pax2a paired box gene 2a protein_coding Danio_rerio
ENSDARG00000032578 pax2b paired box gene 2b protein_coding Danio_rerio
ENSMUSG00000004231 Pax2 paired box 2 protein_coding Mus_musculus

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