C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired box 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004231 Pax2 10090 + 19:44756045-44837871 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000004340 Pax2-201 44757394-44837871 protein_coding
  ENSMUST00000173346 Pax2-004 44759915-44818554 protein_coding
  ENSMUST00000174490 Pax2-001 44756045-44837851 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000004340ENSMUST00000173346ENSMUST00000174490
Transcript ID Adipose Bladder Brain Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000004340 1.448±0.00 0.016±0.00 1.724±2.28 0.010±0.00 0.008±0.00 5.372±1.15 N/A N/A 0.946±0.48 0.439±0.37 0.722±0.35
ENSMUST00000173346 0.874±0.00 0.002±0.00 0.013±0.00 N/A N/A N/A 0.015±0.00 0.020±0.00 N/A 0.027±0.00 N/A
ENSMUST00000174490 0.797±0.06 0.003±0.00 1.354±1.75 N/A N/A 3.434±0.86 0.004±0.00 N/A 0.776±0.26 0.092±0.07 0.401±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QB CIL_0007QB_0002 VISTA 19:44214132-44815870
CIL_00082U CIL_00082U_0002 VISTA 19:44330970-44933041
CIL_00082V CIL_00082V_0002 VISTA 19:44333644-44934226
CIL_00093R CIL_00093R_0002 VISTA 19:44370805-44971431
CIL_00093O CIL_00093O_0002 VISTA 19:44374626-44975238
CIL_0008BC CIL_0008BC_0002 VISTA 19:44398597-45000718
CIL_0008BD CIL_0008BD_0002 VISTA 19:44496521-45098014
CIL_0007U1 CIL_0007U1_0002 VISTA 19:44501251-45102539
CIL_0005DR CIL_0005DR_0002 CGP 19:44562850-44837871
CIL_0007KC CIL_0007KC_0002 UCNEbase 19:44631441-44874931
CIL_0003MX CIL_0003MX_0002 CGP 19:44756045-44983787

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987 IDA core promoter proximal region sequence-specific DNA binding
GO:0001655 IMP:IGI urogenital system development
GO:0001656 IGI metanephros development
GO:0001657 IGI ureteric bud development
GO:0001658 IGI branching involved in ureteric bud morphogenesis
GO:0001709 IMP cell fate determination
GO:0001822 IGI kidney development
GO:0001823 IMP mesonephros development
GO:0001843 IMP neural tube closure
GO:0002072 IMP optic cup morphogenesis involved in camera-type eye development
GO:0003337 IEP mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003406 IMP retinal pigment epithelium development
GO:0003677 IDA DNA binding
GO:0003700 TAS sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 TAS transcription factor complex
GO:0005764 IEA lysosome
GO:0005815 ISS microtubule organizing center
GO:0006351 IEA:IDA transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007417 IEP central nervous system development
GO:0007501 IDA mesodermal cell fate specification
GO:0007568 IEA aging
GO:0008284 IEA positive regulation of cell proliferation
GO:0010001 IMP glial cell differentiation
GO:0016175 IMP superoxide-generating NADPH oxidase activity
GO:0021554 IMP optic nerve development
GO:0021631 IMP optic nerve morphogenesis
GO:0021633 IMP optic nerve structural organization
GO:0021650 IMP vestibulocochlear nerve formation
GO:0031016 IEP pancreas development
GO:0031667 IEA response to nutrient levels
GO:0032993 IDA protein-DNA complex
GO:0034451 ISS centriolar satellite
GO:0035566 IMP regulation of metanephros size
GO:0035799 IMP ureter maturation
GO:0039003 IEP pronephric field specification
GO:0042472 IMP inner ear morphogenesis
GO:0042981 IMP regulation of apoptotic process
GO:0043010 IMP camera-type eye development
GO:0043066 ISS negative regulation of apoptotic process
GO:0043067 IGI regulation of programmed cell death
GO:0043069 IMP negative regulation of programmed cell death
GO:0043154 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043234 IDA protein complex
GO:0043491 IMP protein kinase B signaling
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045918 ISS negative regulation of cytolysis
GO:0045944 IDA:ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048513 IEA organ development
GO:0048793 IMP pronephros development
GO:0048854 IMP brain morphogenesis
GO:0048863 IDA stem cell differentiation
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0055114 IMP oxidation-reduction process
GO:0060231 IMP mesenchymal to epithelial transition
GO:0061205 IMP paramesonephric duct development
GO:0061360 IMP optic chiasma development
GO:0070301 IEP cellular response to hydrogen peroxide
GO:0070742 IPI C2H2 zinc finger domain binding
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071300 IEP cellular response to retinoic acid
GO:0071333 IMP cellular response to glucose stimulus
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0072001 IGI renal system development
GO:0072075 IDA metanephric mesenchyme development
GO:0072108 IGI positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072162 IMP metanephric mesenchymal cell differentiation
GO:0072164 IMP mesonephric tubule development
GO:0072172 IMP mesonephric tubule formation
GO:0072177 IMP mesonephric duct development
GO:0072179 IDA nephric duct formation
GO:0072189 IMP ureter development
GO:0072197 IEP ureter morphogenesis
GO:0072205 IMP metanephric collecting duct development
GO:0072207 IEP metanephric epithelium development
GO:0072221 IMP metanephric distal convoluted tubule development
GO:0072289 IMP metanephric nephron tubule formation
GO:0072300 IMP positive regulation of metanephric glomerulus development
GO:0072305 IMP negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 IMP regulation of metanephric nephron tubule epithelial cell differentiation
GO:0072593 IMP reactive oxygen species metabolic process
GO:0090102 IMP cochlea development
GO:0090103 IMP cochlea morphogenesis
GO:0090190 IMP positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 IMP negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 IMP negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 IMP negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000378 ISS negative regulation of reactive oxygen species metabolic process
GO:2000594 IMP positive regulation of metanephric DCT cell differentiation
GO:2000597 IMP positive regulation of optic nerve formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028148 pax2a paired box gene 2a protein_coding Danio_rerio
ENSDARG00000032578 pax2b paired box gene 2b protein_coding Danio_rerio
ENSG00000075891 PAX2 paired box 2 protein_coding Homo_sapiens

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