C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000077150 NFKB2 9606 + 10:102394110-102402529 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000189444 NFKB2-001 102395706-102402524 protein_coding
  ENST00000336486 NFKB2-008 102398073-102400061 processed_transcript
  ENST00000369966 NFKB2-003 102394597-102402524 protein_coding
  ENST00000428099 NFKB2-201 102394110-102402529 protein_coding
  ENST00000467116 NFKB2-002 102395706-102399218 retained_intron
  ENST00000471698 NFKB2-004 102395693-102396785 protein_coding
  ENST00000473400 NFKB2-005 102400578-102401269 retained_intron
  ENST00000593908 NFKB2-006 102394110-102395958 processed_transcript
  ENST00000601386 NFKB2-007 102394110-102396298 protein_coding
  ENST00000610498 NFKB2-202 102395706-102399215 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000189444ENST00000336486ENST00000369966ENST00000428099ENST00000467116ENST00000610498
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000189444 5.943±0.00 26.349±0.00 0.468±0.00 1.633±1.39 3.725±1.22 6.983±6.58 1.130±0.90 2.498±2.06 0.985±0.51 21.705±19.44 8.682±8.13 14.707±10.13 10.651±1.66 6.863±2.43
ENST00000336486 7.620±0.00 N/A N/A 0.842±0.00 N/A N/A 0.464±0.00 1.873±0.00 3.726±0.00 N/A N/A 27.184±22.00 14.223±0.00 5.798±0.00
ENST00000369966 4.132±0.00 10.324±0.00 N/A N/A 2.398±0.00 4.772±0.00 0.780±0.00 3.858±0.00 0.756±0.00 0.444±0.00 3.004±0.00 5.246±0.00 N/A 3.942±0.00
ENST00000428099 N/A N/A N/A N/A N/A 1.169±0.00 N/A N/A N/A N/A N/A 0.636±0.00 2.668±0.00 N/A
ENST00000467116 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.449±0.00 N/A N/A N/A N/A
ENST00000610498 N/A N/A N/A 0.746±0.61 2.334±0.00 N/A N/A N/A N/A N/A N/A 5.771±4.91 4.683±0.00 1.692±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005WJ CIL_0005WJ_0001 CGP 10:102245532-102402529
CIL_0001HR CIL_0001HR_0002 CGP 10:102394110-102421539

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002268 IEA follicular dendritic cell differentiation
GO:0002467 IEA germinal center formation
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 TAS transcription coactivator activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA:IDA regulation of transcription, DNA-templated
GO:0007165 IEA signal transduction
GO:0030198 IEA extracellular matrix organization
GO:0032481 TAS positive regulation of type I interferon production
GO:0033257 IDA Bcl3/NF-kappaB2 complex
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038061 IEA NIK/NF-kappaB signaling
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087 TAS innate immune response
GO:0048511 IEA rhythmic process
GO:0048536 IEA spleen development
GO:0051092 TAS positive regulation of NF-kappaB transcription factor activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038687 nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 protein_coding Danio_rerio
ENSMUSG00000025225 Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 protein_coding Mus_musculus

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