C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, ATPase, 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087191 PSMC5 9606 + 17:63827152-63832026 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000310144 PSMC5-001 63827183-63832019 protein_coding
  ENST00000375812 PSMC5-201 63827684-63832026 protein_coding
  ENST00000578570 PSMC5-005 63827490-63832018 retained_intron
  ENST00000579031 PSMC5-014 63830065-63831424 retained_intron
  ENST00000579147 PSMC5-003 63827460-63832019 retained_intron
  ENST00000579708 PSMC5-008 63827152-63830917 protein_coding
  ENST00000580063 PSMC5-015 63830682-63831523 retained_intron
  ENST00000580265 PSMC5-009 63827703-63828562 retained_intron
  ENST00000580864 PSMC5-004 63827460-63832019 protein_coding
  ENST00000581764 PSMC5-002 63827460-63831118 retained_intron
  ENST00000581842 PSMC5-018 63827446-63830925 protein_coding
  ENST00000581882 PSMC5-006 63827878-63831986 protein_coding
  ENST00000582130 PSMC5-011 63827453-63831203 protein_coding
  ENST00000582420 PSMC5-010 63827433-63827922 processed_transcript
  ENST00000583283 PSMC5-012 63827460-63829540 retained_intron
  ENST00000584320 PSMC5-020 63827455-63831105 protein_coding
  ENST00000584536 PSMC5-013 63827472-63831425 nonsense_mediated_decay
  ENST00000584657 PSMC5-017 63831339-63832019 retained_intron
  ENST00000584880 PSMC5-016 63830386-63831553 nonsense_mediated_decay
  ENST00000585123 PSMC5-019 63827460-63831151 protein_coding
  ENST00000585242 PSMC5-007 63827479-63831984 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000310144ENST00000375812ENST00000578570ENST00000579147ENST00000580864ENST00000581842ENST00000581882ENST00000582130ENST00000585123ENST00000585242
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000310144 N/A N/A N/A N/A N/A N/A 1.426±0.00 N/A N/A N/A N/A 53.642±0.00 30.565±18.59 N/A
ENST00000375812 21.408±0.00 N/A N/A 45.885±0.00 13.462±0.00 42.850±0.00 N/A 23.267±17.15 N/A 9.423±6.94 N/A 32.020±1.60 35.463±5.76 34.399±0.00
ENST00000578570 N/A N/A N/A N/A N/A 2.187±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000579147 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.283±0.00 N/A N/A N/A N/A
ENST00000580864 23.933±0.00 44.526±0.00 N/A N/A 15.118±0.00 N/A N/A N/A N/A 10.105±0.00 N/A N/A N/A 26.806±0.00
ENST00000581842 N/A N/A 4.198±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000581882 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 45.453±0.00 N/A 65.613±0.00
ENST00000582130 N/A N/A N/A N/A N/A 4.339±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000585123 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 44.555±0.00 N/A
ENST00000585242 46.442±0.00 55.811±0.00 N/A 70.643±0.00 19.267±16.88 N/A N/A 69.223±0.00 26.092±0.00 22.011±0.00 24.829±19.47 32.866±25.52 36.092±9.02 74.419±7.80

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B9 CIL_0009B9_0001 VISTA 17:63374232-63977730
CIL_0006Q4 CIL_0006Q4_0001 CGP 17:63773603-63830012
CIL_0006Q9 CIL_0006Q9_0001 CGP 17:63819433-63832026
CIL_0006QA CIL_0006QA_0001 CGP 17:63827152-63843065

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0003712 TAS transcription cofactor activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005838 IEA proteasome regulatory particle
GO:0006200 IEA ATP catabolic process
GO:0006281 IEA DNA repair
GO:0006310 IEA DNA recombination
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008134 IPI transcription factor binding
GO:0009378 IEA four-way junction helicase activity
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016234 IEA inclusion body
GO:0016787 IEA hydrolase activity
GO:0016887 ISS:IEA ATPase activity
GO:0017025 IEA TBP-class protein binding
GO:0022624 ISS proteasome accessory complex
GO:0030163 IEA protein catabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031410 IDA cytoplasmic vesicle
GO:0031531 IPI thyrotropin-releasing hormone receptor binding
GO:0031595 IEA nuclear proteasome complex
GO:0031597 IEA cytosolic proteasome complex
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0043069 NAS negative regulation of programmed cell death
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle
GO:0090261 IEA positive regulation of inclusion body assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015315 psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 protein_coding Danio_rerio
ENSMUSG00000020708 Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 protein_coding Mus_musculus

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