C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: estrogen receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000091831 ESR1 9606 + 6:151656691-152129619 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000206249 ESR1-001 151807551-152103274 protein_coding
  ENST00000338799 ESR1-002 151804431-152099053 protein_coding
  ENST00000404742 ESR1-004 151690496-151808166 protein_coding
  ENST00000406599 ESR1-009 151807679-152098978 protein_coding
  ENST00000415488 ESR1-010 151880657-152061059 protein_coding
  ENST00000427531 ESR1-008 151809107-152129619 protein_coding
  ENST00000440973 ESR1-201 151690496-152103274 protein_coding
  ENST00000443427 ESR1-202 151807319-152103274 protein_coding
  ENST00000446550 ESR1-007 151807196-151808259 protein_coding
  ENST00000456483 ESR1-203 151807679-152098978 protein_coding
  ENST00000473497 ESR1-005 151656691-151807857 processed_transcript
  ENST00000482101 ESR1-003 151944172-151984165 processed_transcript
  ENST00000488573 ESR1-006 151808105-151811278 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000206249ENST00000338799ENST00000404742ENST00000406599ENST00000415488ENST00000427531ENST00000440973ENST00000443427
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000206249 0.563±0.00 0.217±0.00 N/A N/A N/A N/A N/A N/A 0.338±0.00 N/A 4.120±3.84 N/A
ENST00000338799 N/A N/A N/A 0.536±0.00 N/A N/A N/A N/A 0.418±0.00 N/A N/A N/A
ENST00000404742 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.300±0.00
ENST00000406599 N/A N/A N/A N/A N/A 0.520±0.00 N/A N/A N/A N/A N/A N/A
ENST00000415488 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.610±0.00
ENST00000427531 0.125±0.00 0.273±0.00 0.187±0.06 0.328±0.00 0.410±0.00 0.142±0.00 N/A 0.414±0.00 N/A 0.029±0.00 0.024±0.00 N/A
ENST00000440973 N/A N/A N/A 0.483±0.00 N/A 0.088±0.00 2.888±0.00 1.991±0.00 0.178±0.00 N/A 1.506±1.07 N/A
ENST00000443427 0.276±0.00 N/A N/A 0.935±0.00 0.266±0.00 0.188±0.00 0.775±0.00 0.449±0.00 N/A 0.807±0.00 0.641±0.40 0.249±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005EH CIL_0005EH_0001 CGP 6:151494030-152129619
CIL_0005EI CIL_0005EI_0001 CGP 6:151656691-152637801

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001547 IEA antral ovarian follicle growth
GO:0002064 IEA epithelial cell development
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 NAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 TAS:IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 IEA:ISS steroid binding
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006338 NAS chromatin remodeling
GO:0006351 TAS transcription, DNA-templated
GO:0006355 NAS:IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0007200 ISS phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008209 IEA androgen metabolic process
GO:0008270 IEA zinc ion binding
GO:0008584 IEA male gonad development
GO:0010467 TAS gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0010863 ISS positive regulation of phospholipase C activity
GO:0016020 NAS membrane
GO:0016021 IEA integral component of membrane
GO:0019899 IPI enzyme binding
GO:0030235 NAS nitric-oxide synthase regulator activity
GO:0030284 IEA:NAS estrogen receptor activity
GO:0030518 ISS intracellular steroid hormone receptor signaling pathway
GO:0030520 NAS intracellular estrogen receptor signaling pathway
GO:0032355 IDA response to estradiol
GO:0034056 IDA estrogen response element binding
GO:0035327 IDA transcriptionally active chromatin
GO:0038052 IGI estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042802 IPI identical protein binding
GO:0042981 IEA regulation of apoptotic process
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0043627 IDA response to estrogen
GO:0045429 IDA positive regulation of nitric oxide biosynthetic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048386 IDA positive regulation of retinoic acid receptor signaling pathway
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065 IEA uterus development
GO:0060068 IEA vagina development
GO:0060523 IEA prostate epithelial cord elongation
GO:0060527 IEA prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 IEA regulation of branching involved in prostate gland morphogenesis
GO:0060745 IEA mammary gland branching involved in pregnancy
GO:0060749 IEA mammary gland alveolus development
GO:0060750 IEA epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391 IEA cellular response to estrogen stimulus
GO:0071392 ISS cellular response to estradiol stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004111 esr1 estrogen receptor 1 protein_coding Danio_rerio
ENSMUSG00000019768 Esr1 estrogen receptor 1 (alpha) protein_coding Mus_musculus

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