C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: estrogen receptor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000440973 ESR1-201 ENSG00000091831 9606 + 6:151690496-152103274 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastHeartKidneyLiverLungOvaryENST00000440973
Transcript ID Breast Heart Kidney Liver Lung Ovary
ENST00000440973 0.483±0.00 0.088±0.00 2.888±0.00 1.991±0.00 0.178±0.00 1.506±1.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005EH CIL_0005EH_0001 CGP 6:151494030-152129619
CIL_0005EI CIL_0005EI_0001 CGP 6:151656691-152637801

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001547 IEA antral ovarian follicle growth
GO:0002064 IEA epithelial cell development
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 NAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 TAS:IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 IEA:ISS steroid binding
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0006338 NAS chromatin remodeling
GO:0006351 TAS transcription, DNA-templated
GO:0006355 NAS:IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0007200 ISS phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0008013 IPI beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008209 IEA androgen metabolic process
GO:0008270 IEA zinc ion binding
GO:0008584 IEA male gonad development
GO:0010467 TAS gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0010863 ISS positive regulation of phospholipase C activity
GO:0016020 NAS membrane
GO:0016021 IEA integral component of membrane
GO:0019899 IPI enzyme binding
GO:0030235 NAS nitric-oxide synthase regulator activity
GO:0030284 IEA:NAS estrogen receptor activity
GO:0030518 ISS intracellular steroid hormone receptor signaling pathway
GO:0030520 NAS intracellular estrogen receptor signaling pathway
GO:0032355 IDA response to estradiol
GO:0034056 IDA estrogen response element binding
GO:0035327 IDA transcriptionally active chromatin
GO:0038052 IGI estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042802 IPI identical protein binding
GO:0042981 IEA regulation of apoptotic process
GO:0043124 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0043627 IDA response to estrogen
GO:0045429 IDA positive regulation of nitric oxide biosynthetic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048386 IDA positive regulation of retinoic acid receptor signaling pathway
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065 IEA uterus development
GO:0060068 IEA vagina development
GO:0060523 IEA prostate epithelial cord elongation
GO:0060527 IEA prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 IEA regulation of branching involved in prostate gland morphogenesis
GO:0060745 IEA mammary gland branching involved in pregnancy
GO:0060749 IEA mammary gland alveolus development
GO:0060750 IEA epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391 IEA cellular response to estrogen stimulus
GO:0071392 ISS cellular response to estradiol stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000105589 Esr1-004 protein_coding Mus_musculus 0 2239
ENSMUST00000067086 Esr1-002 protein_coding Mus_musculus 0 2239
ENSMUST00000105590 Esr1-001 protein_coding Mus_musculus 0 2239
ENSMUST00000105588 Esr1-007 protein_coding Mus_musculus 0 1349
ENSMUST00000138828 Esr1-003 retained_intron Mus_musculus 0 1157
ENSMUST00000149195 Esr1-005 processed_transcript Mus_musculus 0 1155
ENSMUST00000137012 Esr1-006 processed_transcript Mus_musculus 0 972
ENSMUST00000127145 Esr1-010 processed_transcript Mus_musculus 0 540
ENSMUST00000127934 Esr1-009 processed_transcript Mus_musculus 0 523

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