C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099817 POLR2E 9606 - 19:1086579-1095380 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000215587 POLR2E-012 1088163-1095374 nonsense_mediated_decay
  ENST00000585838 POLR2E-014 1088645-1095261 protein_coding
  ENST00000586215 POLR2E-008 1088424-1089930 retained_intron
  ENST00000586746 POLR2E-010 1086579-1095354 protein_coding
  ENST00000586817 POLR2E-003 1088167-1095375 retained_intron
  ENST00000589737 POLR2E-006 1088148-1095375 nonsense_mediated_decay
  ENST00000590060 POLR2E-007 1086595-1092346 nonsense_mediated_decay
  ENST00000591709 POLR2E-005 1091501-1095361 retained_intron
  ENST00000591767 POLR2E-002 1088148-1095336 nonsense_mediated_decay
  ENST00000592597 POLR2E-004 1093730-1095349 retained_intron
  ENST00000612655 POLR2E-013 1087645-1095380 protein_coding
  ENST00000614705 POLR2E-011 1089897-1095354 processed_transcript
  ENST00000615234 POLR2E-001 1086579-1095357 protein_coding
  ENST00000619917 POLR2E-009 1088388-1095366 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000215587ENST00000585838ENST00000589737ENST00000591767ENST00000612655ENST00000614705ENST00000615234ENST00000619917
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000215587 48.025±0.00 N/A 1.298±0.00 12.318±6.61 63.832±0.00 35.050±0.00 14.471±13.44 43.041±0.00 23.709±20.35 61.080±0.00 21.516±18.99 32.859±18.13 67.599±15.21 41.823±6.38
ENST00000585838 N/A N/A 2.931±0.00 N/A N/A N/A 26.215±0.00 43.582±0.00 36.608±0.00 N/A 52.571±0.00 5.772±0.00 N/A N/A
ENST00000589737 N/A N/A N/A 2.852±0.00 N/A N/A N/A N/A N/A N/A N/A 44.939±7.18 70.570±4.09 N/A
ENST00000591767 N/A N/A N/A N/A N/A N/A 2.342±0.00 N/A N/A N/A N/A 23.306±0.00 42.282±0.00 21.872±0.00
ENST00000612655 N/A N/A N/A 3.361±0.00 N/A 2.126±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000614705 N/A N/A N/A N/A N/A N/A N/A 17.977±0.00 N/A N/A N/A 27.315±23.56 N/A N/A
ENST00000615234 11.151±0.00 23.508±0.00 0.717±0.00 4.976±4.31 17.773±0.00 3.728±2.87 3.701±0.00 7.476±0.00 3.482±1.53 N/A N/A 7.984±0.00 N/A 6.785±1.10
ENST00000619917 58.223±0.00 N/A N/A 32.031±0.00 77.633±0.00 50.663±0.00 N/A 25.111±0.00 N/A N/A N/A N/A N/A 42.859±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000HU CIL_0000HU_0001 CGP 19:1040101-1086628
CIL_00030S CIL_00030S_0001 CGP 19:1065923-1095380
CIL_0000QU CIL_0000QU_0001 CGP 19:1086579-1106791

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000398 TAS mRNA splicing, via spliceosome
GO:0001054 IBA RNA polymerase I activity
GO:0001055 IBA RNA polymerase II activity
GO:0001056 IBA RNA polymerase III activity
GO:0003677 IEA DNA binding
GO:0003899 IEA DNA-directed RNA polymerase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005665 IDA DNA-directed RNA polymerase II, core complex
GO:0005666 IBA DNA-directed RNA polymerase III complex
GO:0005736 IBA DNA-directed RNA polymerase I complex
GO:0005829 TAS cytosol
GO:0006281 TAS DNA repair
GO:0006283 TAS transcription-coupled nucleotide-excision repair
GO:0006289 TAS nucleotide-excision repair
GO:0006351 IEA transcription, DNA-templated
GO:0006360 IBA transcription from RNA polymerase I promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006368 TAS transcription elongation from RNA polymerase II promoter
GO:0006370 TAS 7-methylguanosine mRNA capping
GO:0006383 TAS transcription from RNA polymerase III promoter
GO:0006385 TAS transcription elongation from RNA polymerase III promoter
GO:0006386 TAS termination of RNA polymerase III transcription
GO:0008380 TAS RNA splicing
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0032481 TAS positive regulation of type I interferon production
GO:0045087 TAS innate immune response
GO:0050434 TAS positive regulation of viral transcription

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026183 polr2eb polymerase (RNA) II (DNA directed) polypeptide E, b protein_coding Danio_rerio
ENSDARG00000074274 POLR2E (2 of 2) polymerase (RNA) II (DNA directed) polypeptide E, 25kDa protein_coding Danio_rerio
ENSMUSG00000004667 Polr2e polymerase (RNA) II (DNA directed) polypeptide E protein_coding Mus_musculus

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