C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) subunit, alpha type, 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100567 PSMA3 9606 + 14:58244831-58272012 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216455 PSMA3-001 58244831-58272007 protein_coding
  ENST00000412908 PSMA3-002 58244877-58272012 protein_coding
  ENST00000553665 PSMA3-008 58244856-58258454 retained_intron
  ENST00000553677 PSMA3-007 58257925-58272006 protein_coding
  ENST00000554207 PSMA3-005 58263524-58267796 retained_intron
  ENST00000554456 PSMA3-014 58244874-58245478 processed_transcript
  ENST00000554812 PSMA3-006 58244846-58268139 retained_intron
  ENST00000555743 PSMA3-016 58244879-58267528 retained_intron
  ENST00000555931 PSMA3-011 58244873-58267504 nonsense_mediated_decay
  ENST00000556321 PSMA3-015 58247789-58258081 retained_intron
  ENST00000557087 PSMA3-012 58244866-58270998 nonsense_mediated_decay
  ENST00000557290 PSMA3-004 58269975-58272004 retained_intron
  ENST00000557508 PSMA3-013 58244904-58272007 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216455ENST00000412908ENST00000554812ENST00000555743ENST00000557087ENST00000557290ENST00000557508
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216455 7.352±0.00 N/A 6.591±0.52 23.136±4.99 13.329±3.36 21.784±12.93 19.009±0.00 26.791±15.07 12.382±3.89 24.794±7.32 39.296±12.03 47.740±13.83 17.308±7.51
ENST00000412908 4.326±0.00 N/A 4.800±0.00 N/A 5.367±0.00 N/A N/A N/A 8.824±0.00 N/A 62.553±0.00 N/A 8.888±0.96
ENST00000554812 N/A N/A 2.425±0.00 N/A 4.717±0.00 2.261±0.00 N/A N/A N/A N/A 6.097±0.00 N/A N/A
ENST00000555743 N/A N/A N/A N/A N/A N/A N/A N/A 9.821±0.00 N/A N/A N/A N/A
ENST00000557087 N/A N/A N/A N/A N/A N/A N/A N/A 13.290±0.00 N/A 107.235±0.00 50.112±0.00 36.092±0.00
ENST00000557290 N/A N/A N/A N/A N/A N/A N/A 6.577±0.00 6.633±0.00 N/A N/A N/A N/A
ENST00000557508 15.089±0.00 38.446±0.00 12.163±0.19 17.993±0.00 8.454±0.00 N/A 49.973±0.00 N/A N/A N/A 32.687±0.00 N/A 12.378±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00022F CIL_00022F_0001 CGP 14:57563922-58298139
CIL_0001K7 CIL_0001K7_0001 CGP 14:58200080-58272012
CIL_0004LX CIL_0004LX_0001 CGP 14:58244831-58373887

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 IEA endopeptidase activity
GO:0004298 IEA threonine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 TAS cytoplasm
GO:0005829 TAS cytosol
GO:0005839 IDA:IEA proteasome core complex
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0019773 IEA proteasome core complex, alpha-subunit complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000086618 psma3 proteasome (prosome, macropain) subunit, alpha type, 3 protein_coding Danio_rerio
ENSMUSG00000060073 Psma3 proteasome (prosome, macropain) subunit, alpha type 3 protein_coding Mus_musculus

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