C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) subunit, alpha type, 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100902 PSMA6 9606 + 14:35278633-35317493 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261479 PSMA6-001 35292357-35317474 protein_coding
  ENST00000540871 PSMA6-002 35278633-35317467 protein_coding
  ENST00000553688 PSMA6-006 35292443-35312899 nonsense_mediated_decay
  ENST00000553809 PSMA6-010 35292398-35317347 protein_coding
  ENST00000554457 PSMA6-005 35312743-35317472 retained_intron
  ENST00000554541 PSMA6-003 35292349-35317457 nonsense_mediated_decay
  ENST00000554620 PSMA6-014 35292393-35314395 nonsense_mediated_decay
  ENST00000554843 PSMA6-008 35292388-35311052 retained_intron
  ENST00000554961 PSMA6-009 35292393-35317474 nonsense_mediated_decay
  ENST00000555050 PSMA6-011 35308775-35310827 retained_intron
  ENST00000555764 PSMA6-004 35292451-35317493 protein_coding
  ENST00000556167 PSMA6-007 35292395-35308436 retained_intron
  ENST00000556221 PSMA6-012 35310833-35317472 protein_coding
  ENST00000556506 PSMA6-013 35292473-35317419 protein_coding
  ENST00000622405 PSMA6-201 35292317-35317478 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261479ENST00000540871ENST00000553809ENST00000554541
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261479 80.750±0.00 80.035±0.00 13.042±0.00 72.630±16.17 45.242±15.24 54.348±18.06 46.108±23.75 75.191±10.81 53.954±15.23 85.742±10.20 94.175±59.31 84.501±11.65 118.249±33.04 106.895±0.00
ENST00000540871 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 108.924±0.00
ENST00000553809 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 230.154±0.00 90.942±0.00 225.435±0.00
ENST00000554541 N/A N/A N/A N/A 31.670±4.93 N/A N/A N/A N/A N/A 14.557±0.00 N/A 45.988±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00045I CIL_00045I_0001 CGP 14:35122549-35317493
CIL_0008MF CIL_0008MF_0001 VISTA 14:35250818-35851792
CIL_0008ME CIL_0008ME_0001 VISTA 14:35273755-35874460
CIL_0001RJ CIL_0001RJ_0001 CGP 14:35278633-35404749

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0000932 ISS cytoplasmic mRNA processing body
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0003723 IDA RNA binding
GO:0004175 NAS:IEA endopeptidase activity
GO:0004298 IEA threonine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005839 ISS:IEA proteasome core complex
GO:0005844 IDA polysome
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016363 ISS nuclear matrix
GO:0019773 TAS:IEA proteasome core complex, alpha-subunit complex
GO:0030016 ISS myofibril
GO:0030017 ISS sarcomere
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035639 NAS purine ribonucleoside triphosphate binding
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0050727 IC regulation of inflammatory response
GO:0051059 IPI NF-kappaB binding
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 IMP:IEA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013966 psma6b proteasome (prosome, macropain) subunit, alpha type, 6b protein_coding Danio_rerio
ENSDARG00000019398 psma6a proteasome (prosome, macropain) subunit, alpha type, 6a protein_coding Danio_rerio
ENSMUSG00000021024 Psma6 proteasome (prosome, macropain) subunit, alpha type 6 protein_coding Mus_musculus

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