C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hepatocyte nuclear factor 4, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101076 HNF4A 9606 + 20:44355700-44432845 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316099 HNF4A-002 44401284-44432845 protein_coding
  ENST00000316673 HNF4A-001 44355700-44429671 protein_coding
  ENST00000372920 HNF4A-003 44401270-44431386 nonsense_mediated_decay
  ENST00000415691 HNF4A-006 44401301-44430500 protein_coding
  ENST00000443598 HNF4A-004 44401284-44424639 protein_coding
  ENST00000457232 HNF4A-005 44355801-44429671 protein_coding
  ENST00000609262 HNF4A-008 44355805-44407474 protein_coding
  ENST00000609795 HNF4A-007 44355801-44424379 protein_coding
  ENST00000619550 HNF4A-201 44355801-44432843 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316099ENST00000372920ENST00000415691ENST00000443598ENST00000457232ENST00000609795ENST00000619550
Transcript ID Bladder Brain Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316099 2.451±0.00 N/A 0.475±0.00 N/A 15.863±0.00 4.957±0.00 0.002±0.00 N/A N/A 0.013±0.00 N/A
ENST00000372920 1.992±0.00 0.061±0.00 3.853±0.00 N/A 5.953±0.00 N/A 0.019±0.00 N/A 0.852±0.73 0.015±0.00 0.608±0.38
ENST00000415691 3.221±0.00 N/A 4.706±0.00 N/A 9.363±0.00 N/A N/A N/A N/A 0.013±0.00 0.402±0.00
ENST00000443598 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.249±0.00
ENST00000457232 N/A N/A N/A N/A N/A N/A N/A 0.421±0.00 N/A N/A N/A
ENST00000609795 N/A N/A N/A 0.021±0.00 N/A N/A N/A 0.040±0.00 N/A 0.048±0.00 N/A
ENST00000619550 N/A 0.052±0.00 N/A N/A N/A N/A 0.016±0.00 N/A N/A N/A 0.213±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007R9 CIL_0007R9_0001 VISTA 20:44272530-44874028
CIL_0006S2 CIL_0006S2_0002 CGP 20:44336986-44432845

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 ISS RNA polymerase II activating transcription factor binding
GO:0003677 IDA DNA binding
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102 IDA receptor binding
GO:0005504 IDA fatty acid binding
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006591 IMP ornithine metabolic process
GO:0006629 IEA lipid metabolic process
GO:0006805 IMP xenobiotic metabolic process
GO:0007548 IEA sex differentiation
GO:0007596 IDA blood coagulation
GO:0008270 IEA zinc ion binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0009749 ISS response to glucose
GO:0010467 TAS gene expression
GO:0010470 IEA regulation of gastrulation
GO:0019216 IDA regulation of lipid metabolic process
GO:0023019 IEA signal transduction involved in regulation of gene expression
GO:0030308 IMP negative regulation of cell growth
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031018 TAS endocrine pancreas development
GO:0042593 ISS glucose homeostasis
GO:0042803 IDA protein homodimerization activity
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0050796 ISS regulation of insulin secretion
GO:0055088 IMP lipid homeostasis
GO:0055091 ISS phospholipid homeostasis
GO:0060395 IEA SMAD protein signal transduction
GO:0060398 NAS regulation of growth hormone receptor signaling pathway
GO:0070328 ISS triglyceride homeostasis
GO:2000189 ISS positive regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021494 hnf4a hepatocyte nuclear factor 4, alpha protein_coding Danio_rerio
ENSMUSG00000017950 Hnf4a hepatic nuclear factor 4, alpha protein_coding Mus_musculus

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