C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hepatic nuclear factor 4, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017950 Hnf4a 10090 + 2:163506808-163572910 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018094 Hnf4a-201 163547188-163572905 protein_coding
  ENSMUST00000109411 Hnf4a-001 163547187-163572910 protein_coding
  ENSMUST00000131658 Hnf4a-003 163546817-163559110 processed_transcript
  ENSMUST00000137449 Hnf4a-004 163550083-163559109 protein_coding
  ENSMUST00000143911 Hnf4a-002 163506808-163552635 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018094ENSMUST00000109411ENSMUST00000143911
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018094 0.014±0.01 0.055±0.02 0.004±0.00 0.155±0.17 153.134±21.16 0.017±0.00 148.276±12.61 75.813±58.43 0.108±0.05 0.010±0.00 0.142±0.04 18.480±11.50 0.021±0.00
ENSMUST00000109411 0.014±0.01 0.024±0.01 0.003±0.00 0.081±0.07 N/A 0.017±0.00 N/A 11.242±7.50 0.098±0.04 0.010±0.00 0.101±0.04 2.889±2.54 0.020±0.00
ENSMUST00000143911 0.104±0.00 N/A N/A N/A N/A N/A N/A N/A 0.289±0.00 N/A 0.778±0.08 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007R9 CIL_0007R9_0002 VISTA 2:163385776-163987192
CIL_0006S2 CIL_0006S2_0003 CGP 2:163492318-163572910
CIL_0002B3 CIL_0002B3_0002 CGP 2:163506808-163619013

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102 IEA receptor binding
GO:0005504 IEA fatty acid binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006591 IEA ornithine metabolic process
GO:0006629 IMP lipid metabolic process
GO:0006805 IEA xenobiotic metabolic process
GO:0007548 IMP sex differentiation
GO:0007596 IEA blood coagulation
GO:0008270 IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009749 IMP response to glucose
GO:0010470 IMP regulation of gastrulation
GO:0019216 IEA regulation of lipid metabolic process
GO:0023019 IDA signal transduction involved in regulation of gene expression
GO:0030308 IEA negative regulation of cell growth
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031018 TAS endocrine pancreas development
GO:0042593 IMP glucose homeostasis
GO:0042803 IEA protein homodimerization activity
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050796 IMP regulation of insulin secretion
GO:0055088 IEA lipid homeostasis
GO:0055091 IMP phospholipid homeostasis
GO:0060395 IDA SMAD protein signal transduction
GO:0070328 IMP triglyceride homeostasis
GO:2000189 IMP positive regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021494 hnf4a hepatocyte nuclear factor 4, alpha protein_coding Danio_rerio
ENSG00000101076 HNF4A hepatocyte nuclear factor 4, alpha protein_coding Homo_sapiens

Loading