C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cholinergic receptor, nicotinic, alpha 4 (neuronal)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000370263 CHRNA4-001 ENSG00000101204 9606 - 20:63344068-63361387 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000370263
Transcript ID Bladder Brain Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000370263 0.349±0.00 4.499±0.00 0.052±0.00 0.038±0.00 0.219±0.10 4.575±0.00 0.081±0.00 0.024±0.01 0.047±0.00 1.752±0.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010A CIL_00010A_0001 CGP 20:63293186-63378401
CIL_0000X3 CIL_0000X3_0001 CGP 20:63343310-63472638

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001508 ISS action potential
GO:0001666 IDA response to hypoxia
GO:0004889 TAS acetylcholine-activated cation-selective channel activity
GO:0005216 IEA ion channel activity
GO:0005230 IEA extracellular ligand-gated ion channel activity
GO:0005515 IEA protein binding
GO:0005886 ISS plasma membrane
GO:0005892 IDA acetylcholine-gated channel complex
GO:0006281 IMP DNA repair
GO:0006810 IEA transport
GO:0006811 NAS:IEA ion transport
GO:0006816 ISS calcium ion transport
GO:0006979 IMP response to oxidative stress
GO:0007165 IDA signal transduction
GO:0007268 NAS synaptic transmission
GO:0007271 ISS synaptic transmission, cholinergic
GO:0007585 IEA respiratory gaseous exchange
GO:0007626 IEA locomotory behavior
GO:0009897 ISS external side of plasma membrane
GO:0014059 ISS regulation of dopamine secretion
GO:0015276 TAS ligand-gated ion channel activity
GO:0015464 IDA acetylcholine receptor activity
GO:0016020 ISS:IEA membrane
GO:0016021 NAS:IEA integral component of membrane
GO:0019233 ISS sensory perception of pain
GO:0030054 IEA cell junction
GO:0030425 ISS dendrite
GO:0034220 TAS ion transmembrane transport
GO:0035094 IDA response to nicotine
GO:0035095 IMP behavioral response to nicotine
GO:0035640 IEA exploration behavior
GO:0042113 ISS B cell activation
GO:0042166 IC acetylcholine binding
GO:0042391 ISS regulation of membrane potential
GO:0043025 ISS neuronal cell body
GO:0045211 IEA postsynaptic membrane
GO:0050877 IMP neurological system process
GO:0050890 IMP cognition
GO:0051899 ISS membrane depolarization
GO:0060080 ISS regulation of inhibitory postsynaptic membrane potential
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000067120 Chrna4-001 protein_coding Mus_musculus 0 1836
ENSMUST00000108851 Chrna4-002 protein_coding Mus_musculus 0 1783
ENSMUST00000022620 Chrna2-001 protein_coding Mus_musculus 0 869
ENSDART00000033947 chrna2a-001 protein_coding Danio_rerio 0 623
ENSDART00000079613 chrna2b-201 protein_coding Danio_rerio 0 604
ENSDART00000136317 chrna2b-001 protein_coding Danio_rerio 0 604
ENSMUST00000135766 Chrna4-004 nonsense_mediated_decay Mus_musculus 0 568
ENSDART00000127176 CHRNA4 (3 of 3)-201 protein_coding Danio_rerio 0 414
ENSDART00000153740 CHRNA4 (3 of 3)-001 protein_coding Danio_rerio 0 372
ENSDART00000002296 chrna3-201 protein_coding Danio_rerio 0 359
ENSDART00000149976 chrna3-001 protein_coding Danio_rerio 0 359
ENSMUST00000033882 Chrna6-201 protein_coding Mus_musculus 0 276
ENSMUST00000029562 Chrnb2-201 protein_coding Mus_musculus 0 239

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