C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif) ligand 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000107562 CXCL12 9606 - 10:44370165-44386493 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343575 CXCL12-001 44377133-44385092 protein_coding
  ENST00000374426 CXCL12-003 44375867-44385043 protein_coding
  ENST00000374429 CXCL12-002 44370165-44385092 protein_coding
  ENST00000395793 CXCL12-005 44372622-44385092 protein_coding
  ENST00000395794 CXCL12-004 44377164-44385049 protein_coding
  ENST00000395795 CXCL12-201 44372888-44385097 protein_coding
  ENST00000488591 CXCL12-007 44380411-44385070 retained_intron
  ENST00000496375 CXCL12-006 44378557-44386493 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343575ENST00000374426ENST00000374429
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343575 160.803±0.00 225.838±0.00 13.460±0.00 1.914±0.29 40.739±29.13 44.649±36.60 17.322±12.77 27.963±10.48 23.480±3.61 17.804±10.19 9.059±4.87 38.762±33.99 3.201±0.73 20.885±15.45
ENST00000374426 N/A N/A N/A N/A N/A N/A 4.257±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000374429 N/A N/A N/A 0.308±0.00 3.351±2.24 4.610±3.46 3.856±0.00 4.777±0.82 3.306±0.00 2.467±0.00 1.282±0.00 5.761±3.94 1.035±0.37 2.709±1.78

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007QA CIL_0007QA_0001 VISTA 10:43961287-44562544

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001569 IEA patterning of blood vessels
GO:0001666 IEA response to hypoxia
GO:0001667 IEA ameboidal cell migration
GO:0001764 IEA neuron migration
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0005102 TAS receptor binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 IEA extracellular space
GO:0005886 IEA plasma membrane
GO:0006874 TAS cellular calcium ion homeostasis
GO:0006935 TAS chemotaxis
GO:0006955 IEA immune response
GO:0007155 TAS cell adhesion
GO:0007165 TAS signal transduction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007281 IEA germ cell development
GO:0007420 IEA brain development
GO:0008009 TAS:IEA chemokine activity
GO:0008015 TAS blood circulation
GO:0008045 IEA motor neuron axon guidance
GO:0008064 TAS regulation of actin polymerization or depolymerization
GO:0008083 IEA growth factor activity
GO:0008284 IEA positive regulation of cell proliferation
GO:0008344 IEA adult locomotory behavior
GO:0008354 IEA germ cell migration
GO:0009314 IEA response to radiation
GO:0009408 IEA response to heat
GO:0009612 IEA response to mechanical stimulus
GO:0009615 TAS response to virus
GO:0009897 IEA external side of plasma membrane
GO:0022029 IEA telencephalon cell migration
GO:0030334 IEA regulation of cell migration
GO:0030335 IEA positive regulation of cell migration
GO:0031100 IEA organ regeneration
GO:0033603 IEA positive regulation of dopamine secretion
GO:0042098 IEA T cell proliferation
GO:0042379 IMP chemokine receptor binding
GO:0043434 IEA response to peptide hormone
GO:0045236 IDA CXCR chemokine receptor binding
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045785 IDA positive regulation of cell adhesion
GO:0048842 IEA positive regulation of axon extension involved in axon guidance
GO:0050930 IEA induction of positive chemotaxis
GO:0051924 IEA regulation of calcium ion transport
GO:0060326 IDA cell chemotaxis
GO:0070062 IDA extracellular vesicular exosome
GO:0070098 IDA chemokine-mediated signaling pathway
GO:0090026 IDA positive regulation of monocyte chemotaxis
GO:0090280 TAS positive regulation of calcium ion import
GO:1901741 IEA positive regulation of myoblast fusion
GO:1902230 IDA negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1903237 IDA negative regulation of leukocyte tethering or rolling
GO:2000107 IDA negative regulation of leukocyte apoptotic process
GO:2000406 IDA positive regulation of T cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037116 cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) protein_coding Danio_rerio
ENSDARG00000055100 cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) protein_coding Danio_rerio
ENSMUSG00000061353 Cxcl12 chemokine (C-X-C motif) ligand 12 protein_coding Mus_musculus

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