C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif) ligand 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000061353 Cxcl12 10090 + 6:117168535-117181367 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000073043 Cxcl12-003 117168577-117181367 protein_coding
  ENSMUST00000112866 Cxcl12-001 117168535-117175069 protein_coding
  ENSMUST00000112871 Cxcl12-002 117168574-117181366 protein_coding
  ENSMUST00000134244 Cxcl12-004 117168577-117176127 retained_intron
  ENSMUST00000185648 Cxcl12-201 117168535-117175069 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000073043ENSMUST00000112871ENSMUST00000134244ENSMUST00000185648
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000073043 34.469±1.78 6.885±1.60 9.691±0.68 3.024±0.03 26.383±5.17 8.811±0.96 30.551±3.71 9.170±0.97 12.013±7.01 71.803±6.61 8.922±2.12 17.828±10.03 1.414±1.41 1.293±0.67
ENSMUST00000112871 N/A N/A N/A 4.754±2.91 11.602±0.00 N/A N/A 43.879±4.07 43.232±27.03 N/A N/A 13.435±8.52 3.956±2.79 1.245±0.32
ENSMUST00000134244 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.249±0.00 N/A 0.147±0.00
ENSMUST00000185648 129.193±64.77 128.302±7.98 115.803±1.88 11.738±7.40 180.470±93.78 134.305±13.75 21.975±1.49 135.149±29.63 93.598±67.98 67.352±17.34 9.221±2.09 145.319±105.91 7.380±4.99 4.556±2.82

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00055S CIL_00055S_0002 CGP 6:116692630-117181367
CIL_0007QA CIL_0007QA_0002 VISTA 6:116979209-117580409

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001569 IMP patterning of blood vessels
GO:0001666 IEA response to hypoxia
GO:0001667 IMP ameboidal cell migration
GO:0001764 IEA neuron migration
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0005615 IEA extracellular space
GO:0005886 IEA plasma membrane
GO:0006955 IEA immune response
GO:0007281 IDA germ cell development
GO:0007420 IDA brain development
GO:0008009 IDA chemokine activity
GO:0008045 IMP motor neuron axon guidance
GO:0008083 IEA growth factor activity
GO:0008284 IEA positive regulation of cell proliferation
GO:0008344 IEA adult locomotory behavior
GO:0008354 IDA germ cell migration
GO:0009314 IEA response to radiation
GO:0009408 IEA response to heat
GO:0009612 IEA response to mechanical stimulus
GO:0009897 IDA external side of plasma membrane
GO:0022029 IEA telencephalon cell migration
GO:0030334 IDA regulation of cell migration
GO:0030335 IDA positive regulation of cell migration
GO:0031100 IEA organ regeneration
GO:0033603 IEA positive regulation of dopamine secretion
GO:0042098 IMP T cell proliferation
GO:0042379 IEA chemokine receptor binding
GO:0043434 IEA response to peptide hormone
GO:0045236 IEA CXCR chemokine receptor binding
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045785 ISO positive regulation of cell adhesion
GO:0048842 IEA positive regulation of axon extension involved in axon guidance
GO:0050930 IDA induction of positive chemotaxis
GO:0051924 IEA regulation of calcium ion transport
GO:0060326 IEA cell chemotaxis
GO:0070062 IEA extracellular vesicular exosome
GO:0070098 IEA chemokine-mediated signaling pathway
GO:0090026 IEA positive regulation of monocyte chemotaxis
GO:1901741 IMP positive regulation of myoblast fusion
GO:1902230 IEA negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1903237 IEA negative regulation of leukocyte tethering or rolling
GO:2000107 IEA negative regulation of leukocyte apoptotic process
GO:2000406 ISO positive regulation of T cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037116 cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) protein_coding Danio_rerio
ENSDARG00000055100 cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) protein_coding Danio_rerio
ENSG00000107562 CXCL12 chemokine (C-X-C motif) ligand 12 protein_coding Homo_sapiens

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