C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: histone deacetylase 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108840 HDAC5 9606 - 17:44076746-44123702 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000225983 HDAC5-003 44076746-44123638 protein_coding
  ENST00000336057 HDAC5-001 44076754-44123618 protein_coding
  ENST00000586339 HDAC5-013 44078608-44079336 retained_intron
  ENST00000586802 HDAC5-002 44078294-44123275 protein_coding
  ENST00000587135 HDAC5-008 44093781-44123628 protein_coding
  ENST00000587776 HDAC5-011 44091293-44093505 retained_intron
  ENST00000588261 HDAC5-010 44088448-44093187 protein_coding
  ENST00000588419 HDAC5-012 44082584-44086755 retained_intron
  ENST00000588703 HDAC5-007 44093664-44123702 protein_coding
  ENST00000591714 HDAC5-009 44093781-44111341 protein_coding
  ENST00000592385 HDAC5-004 44081571-44092183 retained_intron
  ENST00000593013 HDAC5-005 44081597-44085355 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000225983ENST00000336057ENST00000586802ENST00000587776ENST00000588261ENST00000588419ENST00000592385ENST00000593013
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000225983 N/A N/A N/A N/A 2.628±0.00 4.390±0.00 N/A N/A N/A N/A N/A 5.113±0.38 N/A 2.393±0.82
ENST00000336057 N/A N/A N/A N/A N/A N/A N/A N/A 0.456±0.00 N/A N/A N/A N/A N/A
ENST00000586802 15.242±0.00 8.860±0.00 0.727±0.00 11.006±7.69 9.402±7.85 11.564±10.86 6.691±5.14 7.741±7.04 2.574±1.70 16.082±15.23 28.342±26.70 16.742±8.74 17.225±5.90 11.345±7.21
ENST00000587776 N/A N/A N/A N/A N/A 1.549±0.00 3.058±0.00 N/A N/A N/A 2.546±0.00 N/A N/A N/A
ENST00000588261 N/A N/A 2.692±0.00 N/A N/A N/A N/A 1.206±0.00 N/A 3.722±0.00 N/A 10.661±0.00 N/A N/A
ENST00000588419 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.641±0.00 N/A 52.300±0.00 28.911±0.00 13.734±0.00
ENST00000592385 N/A 2.522±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000593013 N/A N/A 0.756±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009B6 CIL_0009B6_0001 VISTA 17:43966083-44567774
CIL_0005J5 CIL_0005J5_0001 CGP 17:44070735-44123702
CIL_0005J4 CIL_0005J4_0001 CGP 17:44076746-44162476

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000118 TAS:IEA histone deacetylase complex
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IDA core promoter binding
GO:0002076 IEA osteoblast development
GO:0003714 IEA transcription corepressor activity
GO:0004407 IDA:IEA histone deacetylase activity
GO:0005080 IPI protein kinase C binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005794 IDA Golgi apparatus
GO:0005829 IEA cytosol
GO:0006325 TAS chromatin organization
GO:0006338 TAS chromatin remodeling
GO:0006342 TAS chromatin silencing
GO:0006351 IEA transcription, DNA-templated
GO:0006954 TAS inflammatory response
GO:0007219 TAS Notch signaling pathway
GO:0007507 IEA heart development
GO:0008134 IPI transcription factor binding
GO:0010830 ISS regulation of myotube differentiation
GO:0010832 IMP negative regulation of myotube differentiation
GO:0016568 TAS:IEA chromatin modification
GO:0016575 IDA histone deacetylation
GO:0016604 IEA nuclear body
GO:0030183 TAS B cell differentiation
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032869 NAS cellular response to insulin stimulus
GO:0033555 IEA multicellular organismal response to stress
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042113 TAS B cell activation
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0043234 IEA protein complex
GO:0043393 IMP regulation of protein binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045668 IEA negative regulation of osteoblast differentiation
GO:0045892 TAS negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048742 IEA regulation of skeletal muscle fiber development
GO:0051091 IMP positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153 IEA regulation of striated muscle cell differentiation
GO:0070491 IPI repressing transcription factor binding
GO:0070932 IEA histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0090051 IMP negative regulation of cell migration involved in sprouting angiogenesis
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075139 hdac5 histone deacetylase 5 protein_coding Danio_rerio
ENSMUSG00000008855 Hdac5 histone deacetylase 5 protein_coding Mus_musculus

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