C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leucine proline-enriched proteoglycan (leprecan) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117385 LEPRE1 9606 - 1:42746335-42767084 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000236040 LEPRE1-002 42746375-42767012 protein_coding
  ENST00000296388 LEPRE1-001 42746375-42767023 protein_coding
  ENST00000372526 LEPRE1-012 42759257-42767002 protein_coding
  ENST00000397054 LEPRE1-201 42746335-42767084 protein_coding
  ENST00000431412 LEPRE1-008 42747723-42755209 nonsense_mediated_decay
  ENST00000447502 LEPRE1-011 42751725-42754987 protein_coding
  ENST00000460031 LEPRE1-009 42746374-42766989 retained_intron
  ENST00000460831 LEPRE1-005 42747758-42748743 retained_intron
  ENST00000462474 LEPRE1-007 42746508-42747798 processed_transcript
  ENST00000463465 LEPRE1-010 42754980-42762403 retained_intron
  ENST00000472802 LEPRE1-006 42746531-42747576 retained_intron
  ENST00000481465 LEPRE1-013 42749901-42754936 retained_intron
  ENST00000492956 LEPRE1-003 42759986-42767017 retained_intron
  ENST00000495874 LEPRE1-004 42746375-42767022 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000236040ENST00000296388ENST00000372526ENST00000431412ENST00000447502ENST00000460031ENST00000462474ENST00000463465ENST00000481465ENST00000492956ENST00000495874
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000236040 N/A N/A N/A 1.300±0.00 N/A N/A 0.463±0.00 N/A N/A 4.562±0.00 N/A 3.021±1.01 N/A 3.316±0.00
ENST00000296388 11.937±0.00 N/A 0.669±0.00 N/A 3.850±3.31 2.737±0.00 1.723±0.00 3.396±2.05 6.480±0.00 N/A N/A 7.943±4.65 54.613±8.74 11.110±0.69
ENST00000372526 N/A N/A N/A N/A 5.169±0.00 2.148±0.00 N/A 4.321±0.00 N/A N/A 1.387±0.00 N/A N/A N/A
ENST00000431412 N/A N/A N/A N/A N/A N/A 1.771±0.00 7.172±0.00 5.936±0.00 N/A N/A N/A N/A N/A
ENST00000447502 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 45.598±0.00 N/A
ENST00000460031 N/A 5.746±0.00 N/A N/A 2.300±0.00 0.932±0.52 N/A 2.022±0.00 0.890±0.00 4.594±0.00 1.519±0.00 2.767±2.00 N/A 5.270±0.00
ENST00000462474 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.590±0.00 N/A 9.543±0.00 N/A 19.779±0.00
ENST00000463465 N/A N/A N/A 0.492±0.00 N/A N/A N/A N/A 1.348±0.00 N/A N/A N/A N/A N/A
ENST00000481465 N/A N/A 0.968±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000492956 N/A N/A N/A 0.460±0.00 N/A N/A N/A N/A N/A N/A 0.190±0.00 N/A N/A N/A
ENST00000495874 N/A N/A N/A 0.791±0.65 0.593±0.00 N/A 0.386±0.19 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PM CIL_0008PM_0001 VISTA 1:42456139-43057783
CIL_0005B1 CIL_0005B1_0002 CGP 1:42733093-42767084
CIL_0005B2 CIL_0005B2_0002 CGP 1:42746335-42794493

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003674 ND molecular_function
GO:0005506 IEA iron ion binding
GO:0005518 ISS collagen binding
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005788 TAS endoplasmic reticulum lumen
GO:0006457 IMP protein folding
GO:0008285 NAS negative regulation of cell proliferation
GO:0016020 IDA membrane
GO:0016049 IEA cell growth
GO:0016491 IEA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018126 IMP protein hydroxylation
GO:0019511 IEA peptidyl-proline hydroxylation
GO:0019797 ISS procollagen-proline 3-dioxygenase activity
GO:0030198 TAS extracellular matrix organization
GO:0030199 IEA collagen fibril organization
GO:0030278 IEA regulation of ossification
GO:0031418 IEA L-ascorbic acid binding
GO:0032403 ISS protein complex binding
GO:0032963 ISS collagen metabolic process
GO:0032991 ISS macromolecular complex
GO:0050708 IMP regulation of protein secretion
GO:0050821 IMP protein stabilization
GO:0055114 IEA oxidation-reduction process
GO:0060348 IMP bone development
GO:0061077 ISS chaperone-mediated protein folding
GO:0070062 IDA extracellular vesicular exosome
GO:1901874 IMP negative regulation of post-translational protein modification

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071212 lepre1 leucine proline-enriched proteoglycan (leprecan) 1 protein_coding Danio_rerio
ENSMUSG00000028641 Lepre1 leprecan 1 protein_coding Mus_musculus

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