C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prospero homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117707 PROX1 9606 + 1:213983181-214041502 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261454 PROX1-201 213988501-214041502 protein_coding
  ENST00000366958 PROX1-001 213987943-214041252 protein_coding
  ENST00000435016 PROX1-002 213988517-214036423 protein_coding
  ENST00000471129 PROX1-004 213983181-213997225 protein_coding
  ENST00000498508 PROX1-202 213987935-214041502 protein_coding
  ENST00000607425 PROX1-006 213989718-213996964 protein_coding
  ENST00000607726 PROX1-005 213987954-213988647 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000366958ENST00000435016ENST00000471129ENST00000498508ENST00000607726
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000366958 0.412±0.00 0.577±0.00 N/A 3.586±0.00 0.701±0.48 0.418±0.07 2.957±2.65 10.391±8.87 6.043±5.54 0.445±0.03 0.584±0.25 2.909±2.05 0.077±0.05 0.530±0.22
ENST00000435016 N/A N/A 0.607±0.00 N/A N/A N/A 1.072±0.00 14.555±0.00 N/A 0.355±0.00 N/A 4.269±0.00 N/A 2.955±1.41
ENST00000471129 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.111±0.00
ENST00000498508 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.227±0.00 N/A N/A
ENST00000607726 N/A N/A 18.647±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007J3 CIL_0007J3_0001 UCNEbase 1:213159436-214186583
CIL_00089Q CIL_00089Q_0001 VISTA 1:213807252-214408737

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 ISS core promoter sequence-specific DNA binding
GO:0001709 IEA cell fate determination
GO:0001822 IEP kidney development
GO:0001889 IEP liver development
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0001945 IEA lymph vessel development
GO:0001946 IDA lymphangiogenesis
GO:0002088 IEP lens development in camera-type eye
GO:0002089 IEA lens morphogenesis in camera-type eye
GO:0002194 IEA hepatocyte cell migration
GO:0003677 IMP:IEA DNA binding
GO:0003700 IC sequence-specific DNA binding transcription factor activity
GO:0003705 ISS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007420 IEP brain development
GO:0007623 IEA circadian rhythm
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0010468 IDA regulation of gene expression
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0016922 IPI ligand-dependent nuclear receptor binding
GO:0021516 ISS dorsal spinal cord development
GO:0021542 ISS dentate gyrus development
GO:0021707 ISS cerebellar granule cell differentiation
GO:0021915 ISS neural tube development
GO:0030240 ISS skeletal muscle thin filament assembly
GO:0030324 IEP lung development
GO:0030910 ISS olfactory placode formation
GO:0031016 IEP pancreas development
GO:0031667 IEA response to nutrient levels
GO:0042752 IMP regulation of circadian rhythm
GO:0043049 ISS otic placode formation
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045071 IDA negative regulation of viral genome replication
GO:0045446 IEA endothelial cell differentiation
GO:0045737 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 ISS positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046619 ISS optic placode formation involved in camera-type eye formation
GO:0048839 IEA inner ear development
GO:0048845 ISS venous blood vessel morphogenesis
GO:0050692 IPI DBD domain binding
GO:0050693 IPI LBD domain binding
GO:0055005 ISS ventricular cardiac myofibril assembly
GO:0055009 ISS atrial cardiac muscle tissue morphogenesis
GO:0055010 ISS ventricular cardiac muscle tissue morphogenesis
GO:0060042 ISS retina morphogenesis in camera-type eye
GO:0060059 IEP embryonic retina morphogenesis in camera-type eye
GO:0060214 ISS endocardium formation
GO:0060298 ISS positive regulation of sarcomere organization
GO:0060412 ISS ventricular septum morphogenesis
GO:0060414 ISS aorta smooth muscle tissue morphogenesis
GO:0060421 ISS positive regulation of heart growth
GO:0060836 IDA lymphatic endothelial cell differentiation
GO:0060849 IMP regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0061114 IEA branching involved in pancreas morphogenesis
GO:0070309 IEP lens fiber cell morphogenesis
GO:0070365 IEP hepatocyte differentiation
GO:0070858 IMP negative regulation of bile acid biosynthetic process
GO:0072574 IEA hepatocyte proliferation
GO:0090425 IEA acinar cell differentiation
GO:0097150 ISS neuronal stem cell maintenance
GO:1901978 IEA positive regulation of cell cycle checkpoint
GO:2000179 ISS positive regulation of neural precursor cell proliferation
GO:2000979 ISS positive regulation of forebrain neuron differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055158 prox1a prospero-related homeobox gene 1a protein_coding Danio_rerio
ENSMUSG00000010175 Prox1 prospero homeobox 1 protein_coding Mus_musculus

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