C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prospero homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000010175 Prox1 10090 - 1:190118035-190170714 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000010319 Prox1-003 190122453-190169399 protein_coding
  ENSMUST00000175916 Prox1-001 190118035-190170714 protein_coding
  ENSMUST00000177288 Prox1-002 190121775-190170233 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000010319ENSMUST00000175916ENSMUST00000177288
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000010319 N/A N/A N/A 1.983±0.00 0.237±0.00 0.207±0.00 1.424±0.00 0.632±0.22 N/A N/A N/A 0.369±0.00 0.086±0.00 2.108±0.68
ENSMUST00000175916 0.577±0.49 11.261±0.81 0.321±0.02 3.310±2.20 1.194±0.40 0.756±0.12 3.641±1.52 1.328±0.30 7.593±4.25 0.567±0.08 0.451±0.07 1.170±0.64 0.144±0.10 0.394±0.00
ENSMUST00000177288 0.037±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.071±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00089Q CIL_00089Q_0002 VISTA 1:189761322-190362331
CIL_0003Z6 CIL_0003Z6_0002 CGP 1:189880492-190170714
CIL_0007J3 CIL_0007J3_0002 UCNEbase 1:189990273-190853986

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001709 IMP cell fate determination
GO:0001822 IEA kidney development
GO:0001889 IEA liver development
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0001945 IMP lymph vessel development
GO:0001946 IEA lymphangiogenesis
GO:0002088 IEA lens development in camera-type eye
GO:0002089 IMP lens morphogenesis in camera-type eye
GO:0002194 IMP hepatocyte cell migration
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007420 IEA brain development
GO:0007623 IEP circadian rhythm
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0010468 IMP regulation of gene expression
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0016922 IEA ligand-dependent nuclear receptor binding
GO:0021542 IMP dentate gyrus development
GO:0021707 IMP cerebellar granule cell differentiation
GO:0030240 IMP skeletal muscle thin filament assembly
GO:0030324 IEA lung development
GO:0031016 IEA pancreas development
GO:0031667 IEA response to nutrient levels
GO:0042752 ISS regulation of circadian rhythm
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045071 IEA negative regulation of viral genome replication
GO:0045446 IMP endothelial cell differentiation
GO:0045737 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045787 IMP positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046619 IEP optic placode formation involved in camera-type eye formation
GO:0048839 IMP inner ear development
GO:0048845 IMP venous blood vessel morphogenesis
GO:0050692 IEA DBD domain binding
GO:0050693 IEA LBD domain binding
GO:0055005 IMP ventricular cardiac myofibril assembly
GO:0055009 IMP atrial cardiac muscle tissue morphogenesis
GO:0055010 IMP ventricular cardiac muscle tissue morphogenesis
GO:0060059 IEP embryonic retina morphogenesis in camera-type eye
GO:0060214 IMP endocardium formation
GO:0060298 IMP positive regulation of sarcomere organization
GO:0060412 IMP ventricular septum morphogenesis
GO:0060414 IMP aorta smooth muscle tissue morphogenesis
GO:0060421 IMP positive regulation of heart growth
GO:0060836 IMP lymphatic endothelial cell differentiation
GO:0060849 IEA regulation of transcription involved in lymphatic endothelial cell fate commitment
GO:0061114 IMP branching involved in pancreas morphogenesis
GO:0070309 IMP lens fiber cell morphogenesis
GO:0070365 IEP hepatocyte differentiation
GO:0070858 IEA negative regulation of bile acid biosynthetic process
GO:0072574 IMP hepatocyte proliferation
GO:0090425 IMP acinar cell differentiation
GO:0097150 IMP neuronal stem cell maintenance
GO:1901978 IMP positive regulation of cell cycle checkpoint
GO:2000179 IMP positive regulation of neural precursor cell proliferation
GO:2000979 IMP positive regulation of forebrain neuron differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055158 prox1a prospero-related homeobox gene 1a protein_coding Danio_rerio
ENSG00000117707 PROX1 prospero homeobox 1 protein_coding Homo_sapiens

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