C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cathepsin D
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117984 CTSD 9606 - 11:1752752-1763992 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000236671 CTSD-001 1752752-1763992 protein_coding
  ENST00000367196 CTSD-002 1757324-1762403 protein_coding
  ENST00000429746 CTSD-004 1753383-1754946 protein_coding
  ENST00000433655 CTSD-006 1752775-1763901 nonsense_mediated_decay
  ENST00000438213 CTSD-005 1754024-1761540 protein_coding
  ENST00000497544 CTSD-003 1753805-1755348 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000236671ENST00000429746ENST00000433655ENST00000438213
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000236671 250.278±0.00 267.725±0.00 15.564±0.00 68.497±54.09 192.537±170.46 85.469±73.32 121.928±111.56 384.184±345.45 133.277±121.66 181.112±148.15 267.977±256.17 201.142±121.21 369.209±87.36 89.608±3.52
ENST00000429746 N/A N/A 8.811±0.00 N/A N/A 7.053±0.00 N/A N/A N/A 17.771±0.00 N/A N/A N/A N/A
ENST00000433655 N/A 62.328±0.00 N/A 34.513±0.00 N/A N/A 129.877±0.00 N/A 135.978±0.00 131.713±0.00 245.837±0.00 140.256±47.57 113.939±0.00 28.883±0.00
ENST00000438213 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.661±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MR CIL_0008MR_0001 VISTA 11:1663842-2266142
CIL_0007RG CIL_0007RG_0001 VISTA 11:1668349-2271510
CIL_00097V CIL_00097V_0001 VISTA 11:1688064-2293510
CIL_00048D CIL_00048D_0001 CGP 11:1732410-1759051
CIL_00048K CIL_00048K_0001 CGP 11:1752752-1837521

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004190 IEA aspartic-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005764 IDA lysosome
GO:0006508 IEA proteolysis
GO:0008219 IEA cell death
GO:0019886 TAS antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030574 TAS collagen catabolic process
GO:0031012 IDA extracellular matrix
GO:0043202 TAS lysosomal lumen
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057698 ctsd cathepsin D protein_coding Danio_rerio
ENSMUSG00000007891 Ctsd cathepsin D protein_coding Mus_musculus

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