C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: suppressor of cytokine signaling 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120833 SOCS2 9606 + 12:93569814-93583487 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340600 SOCS2-001 93569814-93576745 protein_coding
  ENST00000536696 SOCS2-007 93570980-93575197 protein_coding
  ENST00000547229 SOCS2-010 93572135-93572905 protein_coding
  ENST00000548091 SOCS2-008 93571324-93575010 protein_coding
  ENST00000548537 SOCS2-005 93571704-93576206 protein_coding
  ENST00000549122 SOCS2-006 93571361-93576206 protein_coding
  ENST00000549206 SOCS2-002 93570399-93576174 protein_coding
  ENST00000549510 SOCS2-013 93575058-93583487 protein_coding
  ENST00000549887 SOCS2-009 93571900-93575066 protein_coding
  ENST00000551556 SOCS2-011 93571906-93575306 protein_coding
  ENST00000551883 SOCS2-012 93574965-93576019 protein_coding
  ENST00000622746 SOCS2-201 93571681-93576744 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000340600ENST00000536696ENST00000548091ENST00000548537ENST00000549122ENST00000549206ENST00000549510ENST00000551556ENST00000551883
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000340600 3.367±0.00 N/A N/A N/A N/A 2.217±0.00 N/A N/A 1.078±0.00 3.993±0.00 N/A 1.428±1.10 2.671±0.00 N/A
ENST00000536696 N/A N/A 1.425±0.00 N/A N/A N/A 0.453±0.00 N/A N/A 2.680±0.00 N/A N/A 11.847±0.00 4.587±0.00
ENST00000548091 N/A N/A 2.386±0.00 2.218±1.46 N/A 3.216±0.00 0.669±0.00 N/A 3.927±0.00 N/A 0.734±0.00 1.395±0.00 N/A N/A
ENST00000548537 N/A N/A 0.251±0.00 N/A 0.942±0.24 N/A 0.086±0.00 0.587±0.00 N/A N/A 0.176±0.00 0.236±0.02 N/A 0.702±0.00
ENST00000549122 5.877±0.00 4.348±0.00 N/A 1.049±0.00 3.818±0.00 5.461±0.00 1.028±0.62 N/A N/A N/A N/A 4.957±0.79 3.634±0.15 7.170±0.00
ENST00000549206 7.394±0.00 8.904±0.00 N/A 0.863±0.41 1.844±0.97 3.164±1.84 2.567±2.42 16.916±0.00 3.099±1.96 16.560±0.00 0.857±0.00 3.762±2.98 8.262±1.71 7.058±5.89
ENST00000549510 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.817±0.00 N/A N/A
ENST00000551556 N/A N/A 0.700±0.00 N/A 2.644±0.00 N/A N/A 2.226±0.00 1.390±0.00 N/A 0.214±0.00 0.513±0.00 N/A N/A
ENST00000551883 N/A 13.577±0.00 N/A 2.237±0.00 5.070±0.00 8.980±0.00 N/A N/A 4.669±0.00 17.112±0.00 N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 IEA:NAS regulation of cell growth
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005131 NAS growth hormone receptor binding
GO:0005159 IEA:IPI insulin-like growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005737 IEA:NAS cytoplasm
GO:0005829 TAS cytosol
GO:0007259 TAS JAK-STAT cascade
GO:0007568 IEA aging
GO:0008269 IEA JAK pathway signal transduction adaptor activity
GO:0009966 NAS regulation of signal transduction
GO:0009967 TAS positive regulation of signal transduction
GO:0016567 IEA protein ubiquitination
GO:0032355 IDA response to estradiol
GO:0032870 IDA cellular response to hormone stimulus
GO:0035556 IEA intracellular signal transduction
GO:0043066 TAS negative regulation of apoptotic process
GO:0043434 IEA response to peptide hormone
GO:0046426 IEA negative regulation of JAK-STAT cascade
GO:0060396 IDA growth hormone receptor signaling pathway
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045557 socs2 suppressor of cytokine signaling 2 protein_coding Danio_rerio
ENSMUSG00000020027 Socs2 suppressor of cytokine signaling 2 protein_coding Mus_musculus
ENSMUSG00000050974 Gm9847 predicted pseudogene 9847 protein_coding Mus_musculus

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