C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: suppressor of cytokine signaling 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000549206 SOCS2-002 ENSG00000120833 9606 + 12:93570399-93576174 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000549206
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000549206 7.394±0.00 8.904±0.00 0.863±0.41 1.844±0.97 3.164±1.84 2.567±2.42 16.916±0.00 3.099±1.96 16.560±0.00 0.857±0.00 3.762±2.98 8.262±1.71 7.058±5.89

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001558 IEA:NAS regulation of cell growth
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005131 NAS growth hormone receptor binding
GO:0005159 IEA:IPI insulin-like growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005737 IEA:NAS cytoplasm
GO:0005829 TAS cytosol
GO:0007259 TAS JAK-STAT cascade
GO:0008269 IEA JAK pathway signal transduction adaptor activity
GO:0009966 NAS regulation of signal transduction
GO:0009967 TAS positive regulation of signal transduction
GO:0016567 IEA protein ubiquitination
GO:0032355 IDA response to estradiol
GO:0032870 IDA cellular response to hormone stimulus
GO:0035556 IEA intracellular signal transduction
GO:0043066 TAS negative regulation of apoptotic process
GO:0046426 IEA negative regulation of JAK-STAT cascade
GO:0060396 IDA growth hormone receptor signaling pathway
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000172070 Socs2-202 protein_coding Mus_musculus 0 889
ENSMUST00000170690 Socs2-201 protein_coding Mus_musculus 0 889
ENSMUST00000119917 Socs2-008 protein_coding Mus_musculus 0 889
ENSMUST00000020215 Socs2-001 protein_coding Mus_musculus 0 889
ENSMUST00000052528 Gm9847-201 protein_coding Mus_musculus 0 787
ENSMUST00000188378 RP23-458B6.3-001 unprocessed_pseudogene Mus_musculus 0 658
ENSMUST00000134918 Socs2-009 processed_transcript Mus_musculus 0 649
ENSMUST00000139210 Socs2-002 nonsense_mediated_decay Mus_musculus 0 625
ENSMUST00000155148 Socs2-011 processed_transcript Mus_musculus 0 436
ENSMUST00000135822 Socs2-012 protein_coding Mus_musculus 0 422
ENSMUST00000150432 Socs2-007 protein_coding Mus_musculus 0 374
ENSMUST00000129942 Socs2-005 protein_coding Mus_musculus 0 335
ENSMUST00000128363 Socs2-004 processed_transcript Mus_musculus 0 244
ENSMUST00000128854 Socs2-010 processed_transcript Mus_musculus 1e-29 135

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