C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: E2F transcription factor 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129173 E2F8 9606 - 11:19224063-19241620 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000250024 E2F8-002 19224535-19240951 protein_coding
  ENST00000527884 E2F8-001 19224063-19241620 protein_coding
  ENST00000529188 E2F8-005 19225520-19226078 processed_transcript
  ENST00000532666 E2F8-004 19237347-19241598 protein_coding
  ENST00000620009 E2F8-201 19224066-19241620 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000250024ENST00000527884ENST00000532666ENST00000620009
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000250024 0.105±0.00 N/A N/A 0.046±0.00 N/A 0.197±0.04 0.161±0.00 0.013±0.00 0.105±0.00 0.889±0.26 0.352±0.37 0.171±0.09 0.189±0.00
ENST00000527884 N/A 0.094±0.00 0.006±0.00 0.069±0.00 0.116±0.00 0.248±0.00 0.013±0.00 N/A 0.027±0.00 N/A 0.526±0.44 0.308±0.05 0.389±0.04
ENST00000532666 N/A N/A N/A N/A N/A N/A N/A 0.190±0.18 N/A N/A 0.852±0.00 N/A 0.695±0.00
ENST00000620009 0.055±0.00 N/A 0.006±0.00 0.062±0.00 N/A N/A 0.012±0.00 N/A 0.028±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008RI CIL_0008RI_0001 VISTA 11:18872537-19474989
CIL_0008YB CIL_0008YB_0001 VISTA 11:18916805-19520451
CIL_0007HT CIL_0007HT_0002 CGP 11:19182030-19241620
CIL_0004AV CIL_0004AV_0002 CGP 11:19224063-20121598

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047 IDA core promoter binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001890 ISS placenta development
GO:0002040 IMP sprouting angiogenesis
GO:0003677 IEA DNA binding
GO:0003700 IMP:IEA sequence-specific DNA binding transcription factor activity
GO:0003714 ISS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 IEA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0008283 IEA cell proliferation
GO:0032466 ISS negative regulation of cytokinesis
GO:0032877 ISS positive regulation of DNA endoreduplication
GO:0033301 ISS cell cycle comprising mitosis without cytokinesis
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0060707 ISS trophoblast giant cell differentiation
GO:0060718 ISS chorionic trophoblast cell differentiation
GO:0070365 ISS hepatocyte differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057323 e2f8 E2F transcription factor 8 protein_coding Danio_rerio
ENSMUSG00000046179 E2f8 E2F transcription factor 8 protein_coding Mus_musculus

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