C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: E2F transcription factor 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000046179 E2f8 10090 - 7:48866429-48881596 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000058745 E2f8-002 48866429-48881041 protein_coding
  ENSMUST00000119223 E2f8-001 48866429-48881596 protein_coding
  ENSMUST00000136142 E2f8-003 48878833-48881004 retained_intron
  ENSMUST00000151139 E2f8-004 48872107-48875251 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000058745ENSMUST00000119223ENSMUST00000136142ENSMUST00000151139
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000058745 0.723±0.08 N/A 0.092±0.01 1.189±0.18 0.180±0.11 1.120±0.36 0.048±0.00 0.106±0.01 9.652±6.82 0.155±0.00 0.063±0.00 0.775±0.30 14.533±10.16 0.683±0.00
ENSMUST00000119223 0.192±0.14 0.124±0.03 0.119±0.06 0.461±0.32 0.172±0.08 1.083±0.14 0.133±0.02 0.065±0.01 4.477±2.80 0.142±0.05 0.033±0.02 0.989±0.70 19.709±18.90 1.801±0.50
ENSMUST00000136142 N/A N/A N/A N/A N/A N/A 0.024±0.00 N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000151139 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.214±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008RI CIL_0008RI_0002 VISTA 7:48524185-49126415
CIL_0008YB CIL_0008YB_0002 VISTA 7:48559718-49163012
CIL_0007HT CIL_0007HT_0003 CGP 7:48830398-48881596
CIL_0004AV CIL_0004AV_0003 CGP 7:48866429-49610090

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047 IEA core promoter binding
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001890 IMP placenta development
GO:0002040 IMP sprouting angiogenesis
GO:0003677 IDA DNA binding
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0003714 IMP transcription corepressor activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0008283 IDA cell proliferation
GO:0032466 IMP negative regulation of cytokinesis
GO:0032877 IMP positive regulation of DNA endoreduplication
GO:0033301 IMP cell cycle comprising mitosis without cytokinesis
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0060707 IMP trophoblast giant cell differentiation
GO:0060718 IMP chorionic trophoblast cell differentiation
GO:0070365 IMP hepatocyte differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057323 e2f8 E2F transcription factor 8 protein_coding Danio_rerio
ENSG00000129173 E2F8 E2F transcription factor 8 protein_coding Homo_sapiens

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