C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: toll-like receptor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136869 TLR4 9606 + 9:117704332-117716871 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355622 TLR4-001 117704372-117716871 protein_coding
  ENST00000394487 TLR4-002 117704332-117715775 protein_coding
  ENST00000472304 TLR4-003 117704389-117714952 processed_transcript
  ENST00000490685 TLR4-004 117708197-117708979 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355622ENST00000394487ENST00000472304
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355622 12.873±0.00 0.969±0.00 0.968±0.19 1.818±0.21 0.796±0.19 0.876±0.58 2.226±0.76 0.747±0.40 2.392±0.54 N/A 0.495±0.03 2.678±0.63 N/A
ENST00000394487 N/A N/A N/A N/A N/A 0.670±0.00 0.664±0.00 N/A N/A 0.431±0.00 1.193±0.00 N/A 0.060±0.00
ENST00000472304 N/A 0.715±0.00 1.986±0.00 5.194±0.00 1.822±0.00 0.979±0.00 0.752±0.00 3.337±0.00 1.872±0.00 2.351±0.00 1.881±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004FM CIL_0004FM_0001 CGP 9:116687302-117716871
CIL_0007YF CIL_0007YF_0001 VISTA 9:117463172-118064065
CIL_0004FN CIL_0004FN_0001 CGP 9:117704332-119369467

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 ISS activation of MAPK activity
GO:0001530 NAS lipopolysaccharide binding
GO:0001875 IDA lipopolysaccharide receptor activity
GO:0002218 IEA activation of innate immune response
GO:0002224 TAS:IEA toll-like receptor signaling pathway
GO:0002322 IEA B cell proliferation involved in immune response
GO:0002537 IEA nitric oxide production involved in inflammatory response
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004872 TAS receptor activity
GO:0004888 NAS:IEA transmembrane signaling receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006955 TAS:IEA immune response
GO:0007165 IEA signal transduction
GO:0007249 TAS I-kappaB kinase/NF-kappaB signaling
GO:0007252 IDA I-kappaB phosphorylation
GO:0009617 IEA response to bacterium
GO:0009897 IDA external side of plasma membrane
GO:0010008 TAS endosome membrane
GO:0010572 ISS positive regulation of platelet activation
GO:0016021 IEA integral component of membrane
GO:0016046 NAS detection of fungus
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031663 IGI lipopolysaccharide-mediated signaling pathway
GO:0032496 IDA response to lipopolysaccharide
GO:0032497 IDA detection of lipopolysaccharide
GO:0032609 IEA interferon-gamma production
GO:0032689 ISS negative regulation of interferon-gamma production
GO:0032700 ISS negative regulation of interleukin-17 production
GO:0032707 ISS negative regulation of interleukin-23 production
GO:0032715 ISS negative regulation of interleukin-6 production
GO:0032720 ISS negative regulation of tumor necrosis factor production
GO:0032722 IDA positive regulation of chemokine production
GO:0032727 ISS positive regulation of interferon-alpha production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0032732 ISS positive regulation of interleukin-1 production
GO:0032733 ISS positive regulation of interleukin-10 production
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0032874 IEA positive regulation of stress-activated MAPK cascade
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042088 NAS T-helper 1 type immune response
GO:0042116 IMP macrophage activation
GO:0042346 IDA positive regulation of NF-kappaB import into nucleus
GO:0042535 IDA positive regulation of tumor necrosis factor biosynthetic process
GO:0042742 TAS defense response to bacterium
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084 IDA positive regulation of interleukin-12 biosynthetic process
GO:0045087 TAS innate immune response
GO:0045348 IEA positive regulation of MHC class II biosynthetic process
GO:0045359 IEA positive regulation of interferon-beta biosynthetic process
GO:0045416 IDA positive regulation of interleukin-8 biosynthetic process
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045671 NAS negative regulation of osteoclast differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IEA positive regulation of JNK cascade
GO:0046696 IDA lipopolysaccharide receptor complex
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050671 IEA positive regulation of lymphocyte proliferation
GO:0050707 IEA regulation of cytokine secretion
GO:0050727 IEA regulation of inflammatory response
GO:0050729 IC positive regulation of inflammatory response
GO:0050829 IC defense response to Gram-negative bacterium
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051770 ISS positive regulation of nitric-oxide synthase biosynthetic process
GO:0060729 ISS intestinal epithelial structure maintenance
GO:0060907 IEA positive regulation of macrophage cytokine production
GO:0070373 ISS negative regulation of ERK1 and ERK2 cascade
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070430 IEA positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 IEA positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 ISS cellular response to lipopolysaccharide
GO:0071223 IEA cellular response to lipoteichoic acid
GO:0071260 IEP cellular response to mechanical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019742 tlr4ba toll-like receptor 4b, duplicate a protein_coding Danio_rerio
ENSDARG00000022048 tlr4bb toll-like receptor 4b, duplicate b protein_coding Danio_rerio
ENSDARG00000075671 tlr4al toll-like receptor 4a, like protein_coding Danio_rerio
ENSMUSG00000039005 Tlr4 toll-like receptor 4 protein_coding Mus_musculus

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