C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138363 ATIC 9606 + 2:215311817-215349773 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000236959 ATIC-001 215311817-215349763 protein_coding
  ENST00000413174 ATIC-009 215312498-215326978 protein_coding
  ENST00000426233 ATIC-013 215336022-215349298 protein_coding
  ENST00000427397 ATIC-008 215312130-215335004 nonsense_mediated_decay
  ENST00000435675 ATIC-007 215312091-215349763 protein_coding
  ENST00000442048 ATIC-015 215348684-215349773 protein_coding
  ENST00000443953 ATIC-002 215312072-215349763 nonsense_mediated_decay
  ENST00000444305 ATIC-004 215311956-215326056 nonsense_mediated_decay
  ENST00000446622 ATIC-012 215334917-215347652 protein_coding
  ENST00000459796 ATIC-011 215338870-215345587 retained_intron
  ENST00000467388 ATIC-014 215338769-215347240 retained_intron
  ENST00000478734 ATIC-003 215348985-215349756 retained_intron
  ENST00000479093 ATIC-016 215338766-215349733 retained_intron
  ENST00000488712 ATIC-006 215311992-215326139 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000236959ENST00000426233ENST00000435675ENST00000443953ENST00000446622ENST00000467388ENST00000478734ENST00000479093
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000236959 8.077±0.00 9.280±0.00 0.294±0.00 7.895±0.00 4.491±0.00 2.435±1.92 4.240±2.39 5.645±0.00 3.810±0.00 15.723±0.00 13.943±1.07 21.542±6.97 7.042±0.00
ENST00000426233 N/A N/A N/A 1.444±0.00 N/A N/A N/A N/A 2.081±0.00 N/A N/A N/A N/A
ENST00000435675 N/A N/A N/A 1.145±0.00 0.813±0.00 2.080±0.00 N/A N/A N/A 3.732±0.00 4.219±0.00 4.420±0.00 N/A
ENST00000443953 8.163±0.00 13.302±0.00 20.954±0.00 10.991±0.00 6.616±0.00 7.568±0.00 11.988±0.00 8.222±0.00 3.175±0.00 4.070±0.00 5.178±0.95 6.367±0.00 23.050±0.00
ENST00000446622 N/A N/A 1.601±0.00 N/A N/A N/A N/A N/A N/A N/A 4.596±0.00 N/A N/A
ENST00000467388 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.485±0.00 N/A N/A
ENST00000478734 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.531±0.00 N/A N/A N/A
ENST00000479093 N/A 21.997±0.00 8.002±6.73 3.799±0.00 13.075±0.00 N/A 10.847±8.25 7.844±5.52 3.483±0.00 N/A 57.150±35.53 43.771±33.47 27.363±6.42

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005MH CIL_0005MH_0001 CGP 2:214931542-215349773
CIL_0005MI CIL_0005MI_0001 CGP 2:215311817-215436172

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003360 IEA brainstem development
GO:0003824 IEA catalytic activity
GO:0003937 TAS:IEA IMP cyclohydrolase activity
GO:0004643 TAS:IEA phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006139 TAS nucleobase-containing compound metabolic process
GO:0006144 TAS purine nucleobase metabolic process
GO:0006164 IEA purine nucleotide biosynthetic process
GO:0006189 IEA 'de novo' IMP biosynthetic process
GO:0009116 IEA nucleoside metabolic process
GO:0009168 TAS purine ribonucleoside monophosphate biosynthetic process
GO:0009259 IEA ribonucleotide metabolic process
GO:0010035 IEA response to inorganic substance
GO:0016020 IDA membrane
GO:0021549 IEA cerebellum development
GO:0021987 IEA cerebral cortex development
GO:0031100 IEA organ regeneration
GO:0042803 IPI protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0046452 IEA dihydrofolate metabolic process
GO:0046654 IEA tetrahydrofolate biosynthetic process
GO:0055086 TAS nucleobase-containing small molecule metabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016706 atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase protein_coding Danio_rerio
ENSMUSG00000026192 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase protein_coding Mus_musculus

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