C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: poly(A)-specific ribonuclease
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140694 PARN 9606 - 16:14435701-14632728 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000341484 PARN-002 14436605-14630276 protein_coding
  ENST00000420015 PARN-003 14436273-14630259 protein_coding
  ENST00000437198 PARN-001 14435701-14630267 protein_coding
  ENST00000538472 PARN-005 14599935-14630218 nonsense_mediated_decay
  ENST00000539279 PARN-004 14436668-14630238 protein_coding
  ENST00000562715 PARN-012 14576072-14584791 processed_transcript
  ENST00000562896 PARN-006 14627176-14632728 protein_coding
  ENST00000563155 PARN-009 14608107-14610699 retained_intron
  ENST00000563641 PARN-007 14586318-14630260 nonsense_mediated_decay
  ENST00000563697 PARN-013 14555686-14584760 processed_transcript
  ENST00000564113 PARN-011 14555654-14592077 processed_transcript
  ENST00000564882 PARN-014 14446957-14501689 processed_transcript
  ENST00000564904 PARN-015 14482638-14565075 processed_transcript
  ENST00000566021 PARN-008 14610665-14630251 processed_transcript
  ENST00000569444 PARN-010 14555654-14610743 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000341484ENST00000420015ENST00000437198ENST00000539279ENST00000563641ENST00000564904ENST00000566021ENST00000569444
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000341484 N/A 2.386±0.00 0.775±0.00 5.876±0.00 6.064±0.00 4.498±0.00 2.085±0.00 N/A 5.105±0.00 2.207±0.00 0.339±0.00 3.433±0.00 N/A N/A
ENST00000420015 1.240±0.00 N/A N/A N/A 2.350±0.00 1.519±0.00 N/A 1.026±0.00 N/A N/A N/A N/A N/A N/A
ENST00000437198 N/A N/A N/A 1.997±0.00 1.793±0.35 1.083±0.00 1.101±0.00 2.595±1.30 1.416±0.42 1.606±0.93 4.377±0.00 7.406±3.68 6.522±0.89 9.875±3.87
ENST00000539279 1.820±0.00 N/A N/A 3.674±0.00 N/A N/A N/A 1.597±0.00 N/A N/A N/A N/A N/A N/A
ENST00000563641 N/A N/A N/A N/A 4.110±0.00 N/A N/A N/A N/A N/A N/A 10.177±0.00 18.904±0.00 21.331±0.00
ENST00000564904 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.759±0.00 N/A
ENST00000566021 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.044±0.00 N/A N/A N/A
ENST00000569444 N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.279±0.00 N/A 4.959±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007DW CIL_0007DW_0001 CGP 16:14071321-14632728
CIL_0007DV CIL_0007DV_0001 CGP 16:14435701-14669236

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0000184 IMP nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 TAS nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 TAS nuclear-transcribed mRNA poly(A) tail shortening
GO:0003676 IEA nucleic acid binding
GO:0003723 IEA RNA binding
GO:0003730 TAS mRNA 3'-UTR binding
GO:0004518 TAS nuclease activity
GO:0004535 TAS:IEA poly(A)-specific ribonuclease activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 TAS:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006402 IEA mRNA catabolic process
GO:0007292 TAS female gamete generation
GO:0009451 TAS RNA modification
GO:0010467 TAS gene expression
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0019901 IPI protein kinase binding
GO:0044822 IDA poly(A) RNA binding
GO:0046872 IEA metal ion binding
GO:0090305 TAS nucleic acid phosphodiester bond hydrolysis
GO:0090503 IEA RNA phosphodiester bond hydrolysis, exonucleolytic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024702 parn poly(A)-specific ribonuclease (deadenylation nuclease) protein_coding Danio_rerio
ENSMUSG00000022685 Parn poly(A)-specific ribonuclease (deadenylation nuclease) protein_coding Mus_musculus

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