C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interferon regulatory factor 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140968 IRF8 9606 + 16:85898803-85922609 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268638 IRF8-001 85898803-85922609 protein_coding
  ENST00000562492 IRF8-009 85914043-85921371 protein_coding
  ENST00000563180 IRF8-002 85902689-85909882 protein_coding
  ENST00000564056 IRF8-007 85903131-85913312 retained_intron
  ENST00000564617 IRF8-011 85902815-85913160 protein_coding
  ENST00000564803 IRF8-006 85902838-85918800 protein_coding
  ENST00000565552 IRF8-004 85899163-85903156 protein_coding
  ENST00000566369 IRF8-003 85908988-85922296 protein_coding
  ENST00000569145 IRF8-008 85913974-85918489 protein_coding
  ENST00000569607 IRF8-010 85914313-85921274 protein_coding
  ENST00000570088 IRF8-005 85899188-85903531 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000268638ENST00000562492ENST00000563180ENST00000564056ENST00000564617ENST00000564803ENST00000566369ENST00000570088
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000268638 2.159±0.00 40.062±0.00 0.200±0.00 0.534±0.29 2.961±1.70 1.166±0.53 0.537±0.33 0.926±0.00 2.109±0.30 4.076±1.35 0.081±0.00 2.944±0.92 2.012±0.26 2.011±0.00
ENST00000562492 N/A N/A N/A N/A N/A N/A N/A N/A 2.089±0.00 N/A 0.120±0.00 N/A N/A N/A
ENST00000563180 N/A N/A N/A N/A 1.268±0.00 1.122±0.00 0.226±0.00 1.701±0.00 N/A 1.604±0.00 N/A N/A N/A N/A
ENST00000564056 4.722±0.00 N/A N/A 1.319±0.07 N/A N/A 0.780±0.00 4.106±0.00 N/A N/A N/A N/A N/A N/A
ENST00000564617 N/A N/A N/A N/A 4.102±0.00 3.584±0.00 N/A N/A N/A N/A N/A 8.865±1.66 4.903±0.00 1.374±0.00
ENST00000564803 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.746±0.69 N/A 0.528±0.00
ENST00000566369 1.362±0.00 N/A 0.248±0.00 N/A 2.183±0.07 N/A 0.140±0.00 1.686±0.00 N/A N/A N/A 4.132±0.00 1.520±0.00 0.480±0.00
ENST00000570088 N/A N/A 1.023±0.00 N/A N/A N/A N/A N/A 2.187±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000IY CIL_0000IY_0001 CGP 16:85798633-85922609
CIL_0000YG CIL_0000YG_0002 CGP 16:85898803-86515418

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000975 IEA regulatory region DNA binding
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003705 TAS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006909 IEA phagocytosis
GO:0006955 TAS immune response
GO:0009617 IEA response to bacterium
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0030099 IEA myeloid cell differentiation
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032735 IEA positive regulation of interleukin-12 production
GO:0042742 IEA defense response to bacterium
GO:0042832 IEA defense response to protozoan
GO:0044130 IEA negative regulation of growth of symbiont in host
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0060261 IEA positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0071222 IEA cellular response to lipopolysaccharide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056407 irf8 interferon regulatory factor 8 protein_coding Danio_rerio
ENSMUSG00000041515 Irf8 interferon regulatory factor 8 protein_coding Mus_musculus

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