C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RAB5A, member RAS oncogene family
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000144566 RAB5A 9606 + 3:19947079-19985175 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000273047 RAB5A-001 19947079-19985175 protein_coding
  ENST00000412966 RAB5A-008 19947379-19976103 nonsense_mediated_decay
  ENST00000422242 RAB5A-003 19947405-19984450 protein_coding
  ENST00000443878 RAB5A-005 19947250-19950944 protein_coding
  ENST00000446547 RAB5A-002 19947399-19984147 nonsense_mediated_decay
  ENST00000469122 RAB5A-011 19951001-19978891 retained_intron
  ENST00000473608 RAB5A-010 19975516-19984121 retained_intron
  ENST00000476544 RAB5A-007 19947410-19951225 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000273047ENST00000446547ENST00000473608
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000273047 16.856±0.00 10.778±0.00 4.472±0.00 20.362±11.70 9.909±6.76 7.526±6.31 8.655±6.69 10.849±7.98 7.244±2.01 12.597±10.80 4.908±4.50 8.207±4.07 22.313±2.85 11.577±3.47
ENST00000446547 N/A N/A N/A N/A N/A N/A N/A N/A 2.322±0.00 N/A N/A N/A N/A N/A
ENST00000473608 N/A N/A 4.968±0.00 10.836±0.00 N/A 4.041±0.00 N/A 7.653±0.00 5.186±0.00 4.545±0.00 1.750±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002VJ CIL_0002VJ_0002 CGP 3:19879472-19985175
CIL_0004HT CIL_0004HT_0001 CGP 3:19947079-20012330

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 IEA ruffle
GO:0003924 IDA:IEA GTPase activity
GO:0005515 IPI protein binding
GO:0005525 IDA:IEA GTP binding
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005737 IDA:IEA cytoplasm
GO:0005768 ISS endosome
GO:0005769 IDA early endosome
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006184 IDA:IEA GTP catabolic process
GO:0006886 IEA intracellular protein transport
GO:0006897 IDA endocytosis
GO:0006913 IEA nucleocytoplasmic transport
GO:0007165 IEA signal transduction
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007399 IEA nervous system development
GO:0007596 TAS blood coagulation
GO:0008021 ISS synaptic vesicle
GO:0010008 TAS endosome membrane
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0015031 IEA protein transport
GO:0015629 IEA actin cytoskeleton
GO:0016020 IEA membrane
GO:0019001 IEA guanyl nucleotide binding
GO:0019003 IDA GDP binding
GO:0030139 IEA endocytic vesicle
GO:0030154 IEA cell differentiation
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0036465 IDA synaptic vesicle recycling
GO:0036477 IDA somatodendritic compartment
GO:0042589 IEA zymogen granule membrane
GO:0043005 IEA neuron projection
GO:0043025 ISS neuronal cell body
GO:0043195 IDA terminal bouton
GO:0043234 IEA protein complex
GO:0043679 ISS axon terminus
GO:0045022 IMP early endosome to late endosome transport
GO:0045121 IEA membrane raft
GO:0045335 IEA phagocytic vesicle
GO:0045921 IMP positive regulation of exocytosis
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051021 IEA GDP-dissociation inhibitor binding
GO:0051036 IMP regulation of endosome size
GO:0051489 IDA regulation of filopodium assembly
GO:0055037 IEA recycling endosome
GO:0070062 IDA extracellular vesicular exosome
GO:0098559 IMP cytoplasmic side of early endosome membrane
GO:2000286 IMP receptor internalization involved in canonical Wnt signaling pathway
GO:2000300 IMP regulation of synaptic vesicle exocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007257 rab5ab RAB5A, member RAS oncogene family, b protein_coding Danio_rerio
ENSMUSG00000017831 Rab5a RAB5A, member RAS oncogene family protein_coding Mus_musculus

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