C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000161509 GRIN2C 9606 - 17:74842023-74861504 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293190 GRIN2C-001 74842023-74859875 protein_coding
  ENST00000347612 GRIN2C-002 74844032-74860535 protein_coding
  ENST00000578159 GRIN2C-005 74852074-74861504 processed_transcript
  ENST00000584176 GRIN2C-004 74843364-74859872 retained_intron
  ENST00000584496 GRIN2C-003 74853517-74860841 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartLiverMuscleOvaryPlacentaTestisENST00000293190ENST00000347612ENST00000584176ENST00000584496
Transcript ID Adipose Bladder Brain Breast Colon Heart Liver Muscle Ovary Placenta Testis
ENST00000293190 N/A N/A 3.320±0.00 0.036±0.00 N/A N/A 0.021±0.00 N/A 0.192±0.11 1.458±0.00 1.340±0.63
ENST00000347612 N/A N/A N/A 0.085±0.00 0.254±0.00 0.217±0.00 N/A N/A 0.123±0.00 0.459±0.05 1.369±0.93
ENST00000584176 0.063±0.00 0.019±0.00 0.346±0.00 0.042±0.00 0.024±0.00 N/A N/A 0.130±0.00 0.034±0.02 N/A N/A
ENST00000584496 N/A N/A N/A N/A N/A 0.124±0.00 N/A N/A 0.044±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000286 CIL_000286_0001 CGP 17:74776483-74861504
CIL_0001FN CIL_0001FN_0001 CGP 17:74842023-74873031

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004970 IEA ionotropic glutamate receptor activity
GO:0004972 IBA N-methyl-D-aspartate selective glutamate receptor activity
GO:0005234 IBA:IEA extracellular-glutamate-gated ion channel activity
GO:0005261 IEA cation channel activity
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006810 TAS transport
GO:0006812 IEA cation transport
GO:0007215 TAS glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0008104 IEA protein localization
GO:0009611 IEA response to wounding
GO:0014069 IEA postsynaptic density
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0017146 IBA N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 IEA cell junction
GO:0030165 IEA PDZ domain binding
GO:0030425 IBA dendrite
GO:0033058 IEA directional locomotion
GO:0034220 IBA ion transmembrane transport
GO:0035235 IBA ionotropic glutamate receptor signaling pathway
GO:0035249 IBA synaptic transmission, glutamatergic
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042391 IEA regulation of membrane potential
GO:0045211 IBA postsynaptic membrane
GO:0047485 IEA protein N-terminus binding
GO:0050885 IEA neuromuscular process controlling balance
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0098655 IEA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077560 grin2cb glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb protein_coding Danio_rerio
ENSDARG00000078149 grin2ca glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca protein_coding Danio_rerio
ENSMUSG00000020734 Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) protein_coding Mus_musculus

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