C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: COP9 signalosome subunit 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166200 COPS2 9606 - 15:49106068-49155661 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299259 COPS2-003 49127350-49155661 protein_coding
  ENST00000388901 COPS2-001 49122728-49155652 protein_coding
  ENST00000542928 COPS2-002 49127536-49155604 protein_coding
  ENST00000558545 COPS2-004 49139258-49155604 retained_intron
  ENST00000558843 COPS2-006 49134033-49155590 protein_coding
  ENST00000559016 COPS2-007 49134135-49137459 retained_intron
  ENST00000560240 COPS2-008 49106068-49130773 nonsense_mediated_decay
  ENST00000561248 COPS2-005 49134083-49155604 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000299259ENST00000388901ENST00000542928ENST00000558843
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000299259 14.159±0.00 4.469±0.00 N/A 5.668±0.18 7.485±1.95 15.541±11.76 9.348±5.96 9.700±4.70 7.842±1.19 13.981±9.56 16.643±12.63 12.728±3.50 6.889±0.57 16.147±4.41
ENST00000388901 3.140±0.00 0.849±0.00 0.852±0.00 2.257±0.00 2.580±0.73 2.513±1.39 2.150±1.04 2.784±0.00 1.914±0.07 2.121±0.00 2.482±1.79 3.292±0.19 1.602±0.49 4.135±0.16
ENST00000542928 9.600±0.00 9.344±0.00 N/A 11.109±0.00 13.403±0.00 23.688±0.00 8.226±0.00 12.553±0.00 N/A N/A 11.701±0.00 9.469±0.00 4.335±0.00 16.222±0.00
ENST00000558843 N/A N/A 5.491±0.00 11.669±0.00 8.982±0.00 5.976±0.00 5.417±0.00 N/A 8.111±0.00 9.792±0.00 4.004±0.00 13.917±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002PL CIL_0002PL_0001 CGP 15:48988476-49155661
CIL_0004QE CIL_0004QE_0002 CGP 15:49106068-49367869

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0003714 IEA transcription corepressor activity
GO:0004871 NAS signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0007165 NAS signal transduction
GO:0008180 IDA COP9 signalosome
GO:0008283 IEA cell proliferation
GO:0010388 IDA cullin deneddylation
GO:0030182 IEA neuron differentiation
GO:0035914 IEA skeletal muscle cell differentiation
GO:0045892 IEA negative regulation of transcription, DNA-templated

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004785 cops2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) protein_coding Danio_rerio
ENSMUSG00000027206 Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) protein_coding Mus_musculus

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