C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: patched 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185920 PTCH1 9606 - 9:95442980-95517057 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000331920 PTCH1-001 95442980-95508661 protein_coding
  ENST00000375271 PTCH1-005 95468938-95480485 protein_coding
  ENST00000375274 PTCH1-007 95446159-95516965 protein_coding
  ENST00000375290 PTCH1-015 95443412-95506599 nonsense_mediated_decay
  ENST00000418258 PTCH1-201 95442984-95507199 protein_coding
  ENST00000421141 PTCH1-202 95442984-95508040 protein_coding
  ENST00000429896 PTCH1-002 95444162-95507417 protein_coding
  ENST00000430669 PTCH1-003 95443412-95517057 protein_coding
  ENST00000437951 PTCH1-203 95442984-95516965 protein_coding
  ENST00000468211 PTCH1-006 95481829-95517057 protein_coding
  ENST00000488809 PTCH1-004 95479856-95480455 retained_intron
  ENST00000546744 PTCH1-018 95443412-95449936 retained_intron
  ENST00000546820 PTCH1-010 95480061-95508040 protein_coding
  ENST00000547615 PTCH1-024 95456407-95459955 processed_transcript
  ENST00000547672 PTCH1-009 95480061-95508040 protein_coding
  ENST00000548379 PTCH1-022 95480440-95503346 processed_transcript
  ENST00000548420 PTCH1-019 95479996-95506665 protein_coding
  ENST00000548945 PTCH1-013 95480539-95506599 processed_transcript
  ENST00000549678 PTCH1-023 95467287-95469189 retained_intron
  ENST00000550136 PTCH1-017 95481829-95484309 retained_intron
  ENST00000550914 PTCH1-014 95480539-95506599 nonsense_mediated_decay
  ENST00000551425 PTCH1-008 95485824-95516658 processed_transcript
  ENST00000551623 PTCH1-016 95481971-95516658 nonsense_mediated_decay
  ENST00000551630 PTCH1-020 95481966-95506610 protein_coding
  ENST00000551845 PTCH1-011 95480061-95507266 protein_coding
  ENST00000553011 PTCH1-012 95480061-95507199 protein_coding
  ENST00000553256 PTCH1-021 95480544-95494401 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000331920ENST00000375271ENST00000375274ENST00000375290ENST00000421141ENST00000429896ENST00000430669ENST00000437951ENST00000546744ENST00000547615ENST00000549678
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000331920 N/A 0.289±0.00 N/A N/A 1.005±0.00 N/A 0.138±0.00 0.505±0.45 0.085±0.00 0.308±0.00 N/A 0.572±0.07 0.338±0.00 3.642±0.00
ENST00000375271 N/A N/A N/A N/A 6.325±0.00 N/A 0.510±0.00 N/A N/A N/A N/A N/A N/A 8.478±0.00
ENST00000375274 N/A N/A N/A N/A N/A N/A 0.225±0.00 N/A N/A N/A N/A N/A 0.666±0.00 1.591±0.00
ENST00000375290 N/A 0.251±0.00 0.205±0.00 N/A 0.237±0.00 N/A 0.058±0.00 0.023±0.00 0.547±0.00 0.369±0.00 N/A 0.297±0.14 N/A 0.685±0.00
ENST00000421141 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.469±0.14 N/A N/A
ENST00000429896 1.512±0.00 0.654±0.00 0.279±0.00 0.926±0.58 1.051±0.64 1.675±0.00 0.243±0.12 N/A 0.925±0.72 0.443±0.06 0.309±0.28 0.814±0.03 0.806±0.16 2.859±0.00
ENST00000430669 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.619±0.00
ENST00000437951 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.459±0.00 N/A N/A N/A N/A
ENST00000546744 0.905±0.00 1.575±0.00 N/A 0.655±0.30 1.237±0.00 1.181±0.00 0.436±0.00 1.933±0.00 0.305±0.00 0.398±0.00 0.347±0.18 1.227±0.60 0.323±0.00 5.088±2.87
ENST00000547615 N/A N/A N/A N/A N/A N/A N/A 0.689±0.00 N/A N/A N/A N/A N/A N/A
ENST00000549678 N/A N/A N/A N/A N/A N/A 0.864±0.00 N/A N/A N/A 0.497±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002J8 CIL_0002J8_0001 CGP 9:95099054-95517057
CIL_00086R CIL_00086R_0001 VISTA 9:95195577-95797123
CIL_0008KR CIL_0008KR_0001 VISTA 9:95212060-95813032
CIL_0002J7 CIL_0002J7_0001 CGP 9:95442980-96014571

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001701 IEA in utero embryonic development
GO:0001841 IEA neural tube formation
GO:0001843 IEA neural tube closure
GO:0003007 IEA heart morphogenesis
GO:0005113 IEA patched binding
GO:0005119 IPI smoothened binding
GO:0005515 IPI protein binding
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005901 IDA caveola
GO:0007165 IEA signal transduction
GO:0007224 ISS smoothened signaling pathway
GO:0007346 IEA regulation of mitotic cell cycle
GO:0007389 IEA pattern specification process
GO:0007420 ISS brain development
GO:0008158 IEA hedgehog receptor activity
GO:0008201 IEA heparin binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0008544 IEA epidermis development
GO:0008589 ISS regulation of smoothened signaling pathway
GO:0009612 IEA response to mechanical stimulus
GO:0009887 ISS organ morphogenesis
GO:0009953 ISS dorsal/ventral pattern formation
GO:0010157 IEA response to chlorate
GO:0010875 IDA positive regulation of cholesterol efflux
GO:0014069 IEA postsynaptic density
GO:0014070 IEA response to organic cyclic compound
GO:0015485 IDA cholesterol binding
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016485 ISS protein processing
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021532 IMP neural tube patterning
GO:0021904 IEA dorsal/ventral neural tube patterning
GO:0021997 ISS neural plate axis specification
GO:0030326 ISS embryonic limb morphogenesis
GO:0030332 IPI cyclin binding
GO:0030496 IEA midbody
GO:0030879 IEA mammary gland development
GO:0032355 IEA response to estradiol
GO:0032403 IEA protein complex binding
GO:0032526 IEA response to retinoic acid
GO:0032880 IEA regulation of protein localization
GO:0035108 IMP limb morphogenesis
GO:0035137 IEA hindlimb morphogenesis
GO:0040008 IEA regulation of growth
GO:0040015 ISS negative regulation of multicellular organism growth
GO:0042127 IEA regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0042593 IEA glucose homeostasis
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616 IEA keratinocyte proliferation
GO:0044294 IEA dendritic growth cone
GO:0044295 IEA axonal growth cone
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0045879 ISS negative regulation of smoothened signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048568 IEA embryonic organ development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051782 IEA negative regulation of cell division
GO:0060037 IMP pharyngeal system development
GO:0060603 IEA mammary gland duct morphogenesis
GO:0060644 IEA mammary gland epithelial cell differentiation
GO:0060831 IEA smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005 IEA cell differentiation involved in kidney development
GO:0061053 IMP somite development
GO:0071397 ISS cellular response to cholesterol
GO:0072001 IEP renal system development
GO:0072203 IEA cell proliferation involved in metanephros development
GO:0072372 IEA primary cilium
GO:0072661 IDA protein targeting to plasma membrane
GO:0097108 IPI hedgehog family protein binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016404 ptch1 patched 1 protein_coding Danio_rerio
ENSDARG00000095859 ptch1 patched 1 protein_coding Danio_rerio
ENSMUSG00000021466 Ptch1 patched homolog 1 protein_coding Mus_musculus

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