C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: synaptic Ras GTPase activating protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197283 SYNGAP1 9606 + 6:33420070-33453689 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293748 SYNGAP1-004 33420310-33452395 nonsense_mediated_decay
  ENST00000418600 SYNGAP1-001 33420164-33453689 protein_coding
  ENST00000428982 SYNGAP1-003 33431731-33452210 protein_coding
  ENST00000449372 SYNGAP1-009 33420255-33447933 protein_coding
  ENST00000470232 SYNGAP1-008 33446711-33448160 retained_intron
  ENST00000479510 SYNGAP1-002 33420070-33439109 retained_intron
  ENST00000486399 SYNGAP1-007 33446664-33449167 protein_coding
  ENST00000495633 SYNGAP1-005 33438472-33440575 processed_transcript

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartLungMuscleOvaryPlacentaTestisENST00000418600ENST00000428982ENST00000449372ENST00000479510ENST00000486399ENST00000495633
Transcript ID Adrenal Bladder Brain Breast Colon Heart Lung Muscle Ovary Placenta Testis
ENST00000418600 N/A N/A 6.984±5.36 0.644±0.00 N/A 0.399±0.36 1.675±0.00 0.377±0.00 7.077±4.60 0.464±0.02 1.051±0.00
ENST00000428982 N/A N/A 0.514±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000449372 1.274±0.00 0.359±0.00 0.753±0.00 1.055±0.00 0.136±0.00 0.074±0.00 0.361±0.00 N/A 0.335±0.00 0.272±0.00 N/A
ENST00000479510 N/A N/A N/A N/A 0.299±0.00 N/A N/A 0.032±0.00 N/A N/A N/A
ENST00000486399 N/A N/A N/A 3.126±0.00 N/A 0.257±0.00 N/A N/A N/A N/A N/A
ENST00000495633 N/A N/A N/A N/A N/A N/A 7.720±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000253 CIL_000253_0001 CGP 6:33416442-33453689
CIL_000254 CIL_000254_0001 CGP 6:33420070-33457548

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005096 IEA GTPase activator activity
GO:0005097 IEA Rab GTPase activator activity
GO:0005099 IBA Ras GTPase activator activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005737 IBA cytoplasm
GO:0007165 IEA signal transduction
GO:0007265 IEA Ras protein signal transduction
GO:0007389 IEA pattern specification process
GO:0008542 IEA visual learning
GO:0016020 IEA membrane
GO:0016358 IEA dendrite development
GO:0017124 IEA SH3 domain binding
GO:0031235 IBA intrinsic component of the cytoplasmic side of the plasma membrane
GO:0032318 IEA regulation of Ras GTPase activity
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0032851 IEA positive regulation of Rab GTPase activity
GO:0043113 IEA receptor clustering
GO:0043198 IEA dendritic shaft
GO:0043408 IEA regulation of MAPK cascade
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043547 IEA positive regulation of GTPase activity
GO:0046580 ISS negative regulation of Ras protein signal transduction
GO:0048167 ISS regulation of synaptic plasticity
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0050771 IEA negative regulation of axonogenesis
GO:0050803 IEA regulation of synapse structure and activity
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063713 SYNGAP1 (1 of 2) synaptic Ras GTPase activating protein 1 protein_coding Danio_rerio
ENSDARG00000069765 SYNGAP1 (2 of 2) synaptic Ras GTPase activating protein 1 protein_coding Danio_rerio
ENSMUSG00000067629 Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) protein_coding Mus_musculus

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