C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: synaptic Ras GTPase activating protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000418600 SYNGAP1-001 ENSG00000197283 9606 + 6:33420164-33453689 protein_coding

Homo sapiens EnsemblGRCh38

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Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastHeartLungMuscleOvaryPlacentaTestisENST00000418600
Transcript ID Brain Breast Heart Lung Muscle Ovary Placenta Testis
ENST00000418600 6.984±5.36 0.644±0.00 0.399±0.36 1.675±0.00 0.377±0.00 7.077±4.60 0.464±0.02 1.051±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000253 CIL_000253_0001 CGP 6:33416442-33453689
CIL_000254 CIL_000254_0001 CGP 6:33420070-33457548

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005097 IEA Rab GTPase activator activity
GO:0005099 IBA Ras GTPase activator activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005737 IBA cytoplasm
GO:0007165 IEA signal transduction
GO:0007265 IEA Ras protein signal transduction
GO:0007389 IEA pattern specification process
GO:0008542 IEA visual learning
GO:0016020 IEA membrane
GO:0016358 IEA dendrite development
GO:0017124 IEA SH3 domain binding
GO:0031235 IBA intrinsic component of the cytoplasmic side of the plasma membrane
GO:0032318 IEA regulation of Ras GTPase activity
GO:0032320 IBA positive regulation of Ras GTPase activity
GO:0032851 IEA positive regulation of Rab GTPase activity
GO:0043113 IEA receptor clustering
GO:0043198 IEA dendritic shaft
GO:0043408 IEA regulation of MAPK cascade
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0046580 ISS negative regulation of Ras protein signal transduction
GO:0048167 ISS regulation of synaptic plasticity
GO:0048169 IEA regulation of long-term neuronal synaptic plasticity
GO:0050771 IEA negative regulation of axonogenesis
GO:0050803 IEA regulation of synapse structure and activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000177932 Syngap1-202 protein_coding Mus_musculus 0 5452
ENSMUST00000081285 Syngap1-201 protein_coding Mus_musculus 0 5199
ENSDART00000093368 SYNGAP1 (1 of 2)-201 protein_coding Danio_rerio 0 632
ENSDART00000137880 SYNGAP1 (1 of 2)-001 protein_coding Danio_rerio 0 632

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