C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: platelet-derived growth factor alpha polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197461 PDGFA 9606 - 7:497258-520296 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354513 PDGFA-002 498309-519394 protein_coding
  ENST00000400761 PDGFA-005 498493-518508 protein_coding
  ENST00000402802 PDGFA-001 497258-519409 protein_coding
  ENST00000405692 PDGFA-006 512357-520296 protein_coding
  ENST00000426681 PDGFA-004 512445-520208 processed_transcript
  ENST00000482462 PDGFA-003 500778-513467 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000354513ENST00000400761ENST00000402802ENST00000405692
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000354513 N/A N/A 1.309±0.00 N/A 4.146±2.15 5.118±2.70 1.413±0.00 2.921±2.66 0.421±0.00 14.098±0.00 2.728±0.00 17.814±0.00 4.238±0.00 2.679±0.00
ENST00000400761 5.332±0.00 N/A 1.367±0.00 N/A N/A N/A 1.648±0.95 0.218±0.00 2.572±0.00 20.010±0.00 N/A 4.722±0.00 N/A 11.175±0.00
ENST00000402802 4.834±0.00 12.017±0.00 0.749±0.00 3.538±0.04 3.198±0.00 7.759±0.00 1.793±0.59 6.316±0.00 0.564±0.00 7.658±0.00 3.616±0.52 13.776±9.85 15.633±8.89 5.059±0.20
ENST00000405692 N/A N/A N/A N/A 5.975±0.00 N/A N/A N/A 4.768±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018I CIL_00018I_0001 CGP 7:497258-727650

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001525 ISS angiogenesis
GO:0001666 IEA response to hypoxia
GO:0001775 TAS cell activation
GO:0001942 ISS hair follicle development
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002576 TAS platelet degranulation
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005518 IDA collagen binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005902 ISS microvillus
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0007596 TAS blood coagulation
GO:0008083 IDA:IEA growth factor activity
GO:0008284 IDA positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009611 IDA response to wounding
GO:0009887 ISS organ morphogenesis
GO:0009986 IDA cell surface
GO:0010033 IEA response to organic substance
GO:0010035 IEA response to inorganic substance
GO:0010512 IDA negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 IDA negative regulation of platelet activation
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910 IDA regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0030031 ISS cell projection assembly
GO:0030036 ISS actin cytoskeleton organization
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030335 IDA positive regulation of cell migration
GO:0031093 TAS platelet alpha granule lumen
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032355 IEA response to estradiol
GO:0032526 IEA response to retinoic acid
GO:0032956 TAS regulation of actin cytoskeleton organization
GO:0035793 IDA positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 TAS wound healing
GO:0042493 IEA response to drug
GO:0042803 IDA protein homodimerization activity
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043588 ISS skin development
GO:0045087 TAS innate immune response
GO:0045740 IDA positive regulation of DNA replication
GO:0046982 IPI protein heterodimerization activity
GO:0048008 IDA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048286 ISS lung alveolus development
GO:0048407 IPI platelet-derived growth factor binding
GO:0048839 IEA inner ear development
GO:0050730 ISS regulation of peptidyl-tyrosine phosphorylation
GO:0050919 IDA negative chemotaxis
GO:0051781 IEA positive regulation of cell division
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060683 ISS regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:1990401 ISS embryonic lung development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055505 pdgfaa platelet-derived growth factor alpha a protein_coding Danio_rerio
ENSDARG00000058424 pdgfab platelet derived growth factor alpha b protein_coding Danio_rerio
ENSMUSG00000025856 Pdgfa platelet derived growth factor, alpha protein_coding Mus_musculus

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