C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: platelet derived growth factor, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025856 Pdgfa 10090 - 5:138976014-138997370 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000046901 Pdgfa-002 138976516-138994953 protein_coding
  ENSMUST00000076095 Pdgfa-001 138976014-138995037 protein_coding
  ENSMUST00000110896 Pdgfa-003 138976971-138997370 protein_coding
  ENSMUST00000110897 Pdgfa-004 138976942-138996087 protein_coding
  ENSMUST00000124080 Pdgfa-006 138986270-138994484 processed_transcript
  ENSMUST00000132051 Pdgfa-005 138988441-138996001 processed_transcript
  ENSMUST00000144934 Pdgfa-007 138977145-138994281 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046901ENSMUST00000076095ENSMUST00000110896ENSMUST00000110897ENSMUST00000144934
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046901 6.297±3.10 14.871±4.88 5.392±0.00 N/A 5.462±1.34 35.030±1.58 3.193±0.14 4.093±0.54 0.678±0.41 28.551±2.67 4.805±0.30 9.541±3.61 8.578±9.56 1.954±0.43
ENSMUST00000076095 4.988±1.55 8.131±1.35 7.932±0.51 2.868±0.59 2.121±0.63 5.222±0.05 3.392±0.17 2.528±0.44 0.462±0.12 14.974±0.99 4.639±0.92 5.572±1.72 7.412±7.61 1.220±0.02
ENSMUST00000110896 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.402±0.42
ENSMUST00000110897 N/A N/A N/A 10.075±0.00 N/A N/A N/A N/A N/A N/A N/A 6.024±0.00 21.507±16.64 N/A
ENSMUST00000144934 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.724±21.70 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018I CIL_00018I_0002 CGP 5:138976014-139150001

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IDA angiogenesis
GO:0001666 IEA response to hypoxia
GO:0001942 IMP hair follicle development
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0005161 IBA platelet-derived growth factor receptor binding
GO:0005515 IEA protein binding
GO:0005518 IEA collagen binding
GO:0005615 IEA extracellular space
GO:0005902 IDA microvillus
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007596 IBA blood coagulation
GO:0008083 IEA growth factor activity
GO:0008284 IMP positive regulation of cell proliferation
GO:0009611 IEA response to wounding
GO:0009887 IMP organ morphogenesis
GO:0009986 IEA cell surface
GO:0010033 IEA response to organic substance
GO:0010035 IEA response to inorganic substance
GO:0010512 IEA negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 IEA negative regulation of platelet activation
GO:0014068 IBA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910 IEA regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0030031 IDA cell projection assembly
GO:0030036 IDA actin cytoskeleton organization
GO:0030335 IBA positive regulation of cell migration
GO:0031954 IBA positive regulation of protein autophosphorylation
GO:0032355 IEA response to estradiol
GO:0032526 IEA response to retinoic acid
GO:0035793 IEA positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0042060 IEA wound healing
GO:0042493 IEA response to drug
GO:0042803 IEA protein homodimerization activity
GO:0043406 IBA positive regulation of MAP kinase activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043588 IMP skin development
GO:0045740 IEA positive regulation of DNA replication
GO:0046982 IEA protein heterodimerization activity
GO:0048008 IBA platelet-derived growth factor receptor signaling pathway
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048286 IMP lung alveolus development
GO:0048407 IEA platelet-derived growth factor binding
GO:0048839 IEA inner ear development
GO:0050730 IDA regulation of peptidyl-tyrosine phosphorylation
GO:0050919 IEA negative chemotaxis
GO:0051781 IEA positive regulation of cell division
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060683 IMP regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374 IBA positive regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055505 pdgfaa platelet-derived growth factor alpha a protein_coding Danio_rerio
ENSDARG00000058424 pdgfab platelet derived growth factor alpha b protein_coding Danio_rerio
ENSG00000197461 PDGFA platelet-derived growth factor alpha polypeptide protein_coding Homo_sapiens

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