C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: platelet-derived growth factor alpha polypeptide
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000354513 PDGFA-002 ENSG00000197461 9606 - 7:498309-519394 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000354513
Transcript ID Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000354513 1.309±0.00 4.146±2.15 5.118±2.70 1.413±0.00 2.921±2.66 0.421±0.00 14.098±0.00 2.728±0.00 17.814±0.00 4.238±0.00 2.679±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00018I CIL_00018I_0001 CGP 7:497258-727650

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001525 ISS angiogenesis
GO:0001666 IEA response to hypoxia
GO:0001775 TAS cell activation
GO:0001942 ISS hair follicle development
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002576 TAS platelet degranulation
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005518 IDA collagen binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005902 ISS microvillus
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0007596 TAS blood coagulation
GO:0008083 IDA:IEA growth factor activity
GO:0008284 IDA positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009611 IDA response to wounding
GO:0009887 ISS organ morphogenesis
GO:0009986 IDA cell surface
GO:0010033 IEA response to organic substance
GO:0010035 IEA response to inorganic substance
GO:0010512 IDA negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 IDA negative regulation of platelet activation
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014910 IDA regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0030031 ISS cell projection assembly
GO:0030036 ISS actin cytoskeleton organization
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030335 IDA positive regulation of cell migration
GO:0031093 TAS platelet alpha granule lumen
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032355 IEA response to estradiol
GO:0032526 IEA response to retinoic acid
GO:0032956 TAS regulation of actin cytoskeleton organization
GO:0035793 IDA positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042060 TAS wound healing
GO:0042493 IEA response to drug
GO:0042803 IDA protein homodimerization activity
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043588 ISS skin development
GO:0045087 TAS innate immune response
GO:0045740 IDA positive regulation of DNA replication
GO:0046982 IPI protein heterodimerization activity
GO:0048008 IDA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048286 ISS lung alveolus development
GO:0048407 IPI platelet-derived growth factor binding
GO:0048839 IEA inner ear development
GO:0050730 ISS regulation of peptidyl-tyrosine phosphorylation
GO:0050919 IDA negative chemotaxis
GO:0051781 IEA positive regulation of cell division
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060683 ISS regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:1990401 ISS embryonic lung development

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000046901 Pdgfa-002 protein_coding Mus_musculus 0 1223
ENSMUST00000076095 Pdgfa-001 protein_coding Mus_musculus 0 979
ENSMUST00000110896 Pdgfa-003 protein_coding Mus_musculus 0 776
ENSMUST00000110897 Pdgfa-004 protein_coding Mus_musculus 0 774
ENSMUST00000144934 Pdgfa-007 processed_transcript Mus_musculus 0 579
ENSMUST00000124080 Pdgfa-006 processed_transcript Mus_musculus 0 364
ENSMUST00000132051 Pdgfa-005 processed_transcript Mus_musculus 5e-37 159

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