C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polymerase (DNA directed), alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000006678 Pola1 10090 - X:93304767-93632155 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000006856 Pola1-001 93304767-93632155 protein_coding
  ENSMUST00000124236 Pola1-002 93623298-93632115 processed_transcript
  ENSMUST00000127718 Pola1-003 93623076-93632143 retained_intron
  ENSMUST00000142479 Pola1-004 93480490-93490946 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000006856ENSMUST00000124236ENSMUST00000127718
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000006856 0.504±0.24 0.304±0.08 1.048±0.12 1.180±0.50 0.262±0.10 0.462±0.13 0.256±0.14 0.307±0.05 2.317±2.64 0.436±0.04 0.142±0.04 1.354±1.41 2.278±1.80 0.236±0.11
ENSMUST00000124236 N/A 0.586±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.209±0.00 0.547±0.08 N/A 0.322±0.00
ENSMUST00000127718 N/A N/A N/A N/A 0.081±0.00 N/A N/A 0.130±0.00 N/A N/A N/A 0.158±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007PA CIL_0007PA_0002 UCNEbase X:92514784-93497939
CIL_0009CI CIL_0009CI_0002 VISTA X:92999508-93601047
CIL_0008W6 CIL_0008W6_0002 VISTA X:93001146-93602798
CIL_0008W7 CIL_0008W7_0002 VISTA X:93009764-93611448
CIL_0008W8 CIL_0008W8_0002 VISTA X:93076664-93678616
CIL_0008NM CIL_0008NM_0002 VISTA X:93107742-93710584
CIL_0008NL CIL_0008NL_0002 VISTA X:93128674-93730367
CIL_0008NF CIL_0008NF_0002 VISTA X:93157367-93758875
CIL_0008NE CIL_0008NE_0002 VISTA X:93196691-93798662
CIL_00084H CIL_00084H_0002 VISTA X:93277817-93878339

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 ISS nucleotide binding
GO:0000785 ISS chromatin
GO:0001882 IEA nucleoside binding
GO:0003677 ISS DNA binding
GO:0003682 ISS chromatin binding
GO:0003887 ISS DNA-directed DNA polymerase activity
GO:0003896 ISS DNA primase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005635 ISS nuclear envelope
GO:0005654 ISS nucleoplasm
GO:0005658 ISS alpha DNA polymerase:primase complex
GO:0005730 ISS nucleolus
GO:0005737 IEA cytoplasm
GO:0006260 ISS DNA replication
GO:0006269 IEA DNA replication, synthesis of RNA primer
GO:0006270 ISS DNA replication initiation
GO:0006271 ISS DNA strand elongation involved in DNA replication
GO:0006272 ISS leading strand elongation
GO:0006273 ISS lagging strand elongation
GO:0006303 ISS double-strand break repair via nonhomologous end joining
GO:0008283 ISS cell proliferation
GO:0008408 IBA 3'-5' exonuclease activity
GO:0016363 ISS nuclear matrix
GO:0019901 IEA protein kinase binding
GO:0019985 IBA translesion synthesis
GO:0046872 IEA metal ion binding
GO:0046982 IPI protein heterodimerization activity
GO:0051539 IEA 4 iron, 4 sulfur cluster binding
GO:0090305 IBA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045308 pola1 polymerase (DNA directed), alpha 1 protein_coding Danio_rerio
ENSG00000101868 POLA1 polymerase (DNA directed), alpha 1, catalytic subunit protein_coding Homo_sapiens

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