C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: polymerase (DNA directed), alpha 1, catalytic subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101868 POLA1 9606 + X:24693919-24996986 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000379059 POLA1-001 24693947-24996986 protein_coding
  ENST00000379068 POLA1-005 24693919-24996986 protein_coding
  ENST00000480125 POLA1-002 24745503-24810781 processed_transcript
  ENST00000493342 POLA1-003 24726933-24734353 processed_transcript
  ENST00000494204 POLA1-004 24812830-24841983 processed_transcript
  ENST00000611764 POLA1-201 24693947-24996983 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000379059ENST00000379068ENST00000494204ENST00000611764
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000379059 1.853±0.00 0.894±0.00 N/A 0.909±0.00 1.600±0.00 1.330±0.05 N/A 1.696±0.00 0.149±0.00 N/A N/A 0.906±0.00 0.534±0.18 3.328±0.00
ENST00000379068 N/A 0.692±0.00 0.447±0.00 0.159±0.00 N/A 1.002±0.25 0.811±0.63 N/A 0.786±0.00 1.386±0.21 1.284±0.00 2.760±1.26 1.884±0.22 1.603±0.00
ENST00000494204 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.700±0.00 N/A N/A N/A
ENST00000611764 N/A N/A N/A 0.456±0.00 N/A N/A N/A 0.321±0.00 0.242±0.00 N/A 0.499±0.00 0.398±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00084H CIL_00084H_0001 VISTA X:24441239-25041771
CIL_0008NE CIL_0008NE_0001 VISTA X:24504486-25106506
CIL_0008NF CIL_0008NF_0001 VISTA X:24546114-25147616
CIL_0008NL CIL_0008NL_0001 VISTA X:24576218-25177967
CIL_0008NM CIL_0008NM_0001 VISTA X:24597265-25200155
CIL_0008W8 CIL_0008W8_0001 VISTA X:24627531-25229450
CIL_0008W7 CIL_0008W7_0001 VISTA X:24689762-25291464
CIL_0001X9 CIL_0001X9_0002 CGP X:24693919-25015948

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000083 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000166 IDA:IEA nucleotide binding
GO:0000278 TAS mitotic cell cycle
GO:0000722 TAS telomere maintenance via recombination
GO:0000723 TAS telomere maintenance
GO:0000785 IDA chromatin
GO:0001882 IEA nucleoside binding
GO:0003676 IEA nucleic acid binding
GO:0003677 IDA:IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003887 IDA:IEA DNA-directed DNA polymerase activity
GO:0003896 IDA DNA primase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005635 IDA nuclear envelope
GO:0005654 IDA nucleoplasm
GO:0005658 IDA alpha DNA polymerase:primase complex
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0006260 IMP:IEA DNA replication
GO:0006269 IDA DNA replication, synthesis of RNA primer
GO:0006270 IDA DNA replication initiation
GO:0006271 IMP DNA strand elongation involved in DNA replication
GO:0006272 IDA leading strand elongation
GO:0006273 IDA lagging strand elongation
GO:0006303 IMP double-strand break repair via nonhomologous end joining
GO:0008283 IDA cell proliferation
GO:0008408 IBA 3'-5' exonuclease activity
GO:0016032 IEA viral process
GO:0016363 IDA nuclear matrix
GO:0019901 IPI protein kinase binding
GO:0019985 IBA translesion synthesis
GO:0032201 TAS telomere maintenance via semi-conservative replication
GO:0046872 IEA metal ion binding
GO:0046982 IEA protein heterodimerization activity
GO:0051539 IEA 4 iron, 4 sulfur cluster binding
GO:0071897 IEA DNA biosynthetic process
GO:0090305 IBA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045308 pola1 polymerase (DNA directed), alpha 1 protein_coding Danio_rerio
ENSMUSG00000006678 Pola1 polymerase (DNA directed), alpha 1 protein_coding Mus_musculus

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