C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cordon-bleu WH2 repeat
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020173 Cobl 10090 - 11:12236608-12464960 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000046755 Cobl-001 12236676-12464957 protein_coding
  ENSMUST00000109650 Cobl-003 12236676-12464859 protein_coding
  ENSMUST00000109651 Cobl-006 12236678-12464960 protein_coding
  ENSMUST00000130572 Cobl-002 12304867-12464752 retained_intron
  ENSMUST00000136549 Cobl-004 12296363-12369640 protein_coding
  ENSMUST00000146067 Cobl-005 12343847-12378278 protein_coding
  ENSMUST00000172827 Cobl-010 12267007-12369692 protein_coding
  ENSMUST00000172919 Cobl-009 12236608-12464804 protein_coding
  ENSMUST00000172956 Cobl-007 12237111-12464800 nonsense_mediated_decay
  ENSMUST00000174874 Cobl-008 12236678-12412144 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046755ENSMUST00000109650ENSMUST00000109651ENSMUST00000136549ENSMUST00000146067ENSMUST00000172827ENSMUST00000172919ENSMUST00000172956ENSMUST00000174874
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046755 0.648±0.39 N/A N/A 1.676±0.57 0.510±0.15 2.413±0.72 0.277±0.01 1.182±0.19 0.514±0.39 2.167±0.69 N/A 0.675±0.14 0.252±0.18 0.076±0.00
ENSMUST00000109650 0.141±0.00 N/A 0.686±0.00 2.624±2.38 0.590±0.34 0.986±0.10 0.126±0.01 1.148±0.28 0.344±0.27 N/A N/A 1.048±0.55 0.834±0.67 0.324±0.19
ENSMUST00000109651 0.159±0.00 0.178±0.05 N/A 4.195±0.00 0.862±0.00 N/A N/A N/A 0.262±0.12 0.690±0.00 N/A N/A N/A N/A
ENSMUST00000136549 N/A N/A N/A N/A 3.563±0.00 N/A 2.405±0.92 N/A N/A N/A 21.148±2.68 N/A N/A N/A
ENSMUST00000146067 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.611±1.51 N/A N/A N/A
ENSMUST00000172827 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.585±0.00
ENSMUST00000172919 0.159±0.00 N/A N/A N/A 0.764±0.13 N/A 0.205±0.00 1.938±0.21 0.643±0.36 3.075±0.38 N/A 0.783±0.00 0.173±0.01 N/A
ENSMUST00000172956 N/A 0.131±0.06 N/A 2.368±0.00 0.215±0.00 N/A 0.148±0.00 N/A 0.116±0.00 N/A N/A 1.106±0.00 0.194±0.00 0.125±0.02
ENSMUST00000174874 0.063±0.00 0.071±0.03 N/A N/A N/A 2.208±0.58 N/A 1.194±0.00 N/A N/A N/A 0.998±0.10 2.207±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KL CIL_0008KL_0002 VISTA 11:11661856-12262621
CIL_00072I CIL_00072I_0003 CGP 11:11930508-12464960

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000578 IEP embryonic axis specification
GO:0001726 IDA ruffle
GO:0001757 IEP somite specification
GO:0001843 IGI neural tube closure
GO:0001889 IEP liver development
GO:0003779 IEA actin binding
GO:0003785 IDA actin monomer binding
GO:0005515 IPI protein binding
GO:0005884 IDA actin filament
GO:0005886 IEA plasma membrane
GO:0005938 IDA cell cortex
GO:0016020 IDA membrane
GO:0030041 IMP actin filament polymerization
GO:0030424 IDA axon
GO:0030425 IDA dendrite
GO:0030903 IEP notochord development
GO:0033504 IEP floor plate development
GO:0043025 IDA neuronal cell body
GO:0044294 IDA dendritic growth cone
GO:0044295 IDA axonal growth cone
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048565 IEP digestive tract development
GO:0048669 IMP collateral sprouting in absence of injury
GO:0051639 IDA actin filament network formation
GO:0051764 NAS actin crosslink formation
GO:1900006 IDA positive regulation of dendrite development
GO:1900029 IDA positive regulation of ruffle assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091006 cobl cordon-bleu homolog (mouse) protein_coding Danio_rerio
ENSG00000106078 COBL cordon-bleu WH2 repeat protein protein_coding Homo_sapiens

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