C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine hydroxymethyltransferase 1 (soluble)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020534 Shmt1 10090 - 11:60788104-60811718 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018744 Shmt1-001 60788104-60811265 protein_coding
  ENSMUST00000124227 Shmt1-003 60792949-60797853 retained_intron
  ENSMUST00000135081 Shmt1-002 60789596-60793173 retained_intron
  ENSMUST00000172659 Shmt1-009 60804345-60811718 processed_transcript
  ENSMUST00000172804 Shmt1-011 60789248-60794997 retained_intron
  ENSMUST00000173260 Shmt1-004 60797245-60811091 retained_intron
  ENSMUST00000173698 Shmt1-008 60798652-60802670 processed_transcript
  ENSMUST00000174093 Shmt1-005 60788901-60799403 processed_transcript
  ENSMUST00000174174 Shmt1-007 60789144-60807021 nonsense_mediated_decay
  ENSMUST00000174214 Shmt1-010 60789144-60807021 protein_coding
  ENSMUST00000174719 Shmt1-006 60789144-60807021 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENSMUST00000018744ENSMUST00000173260ENSMUST00000174093ENSMUST00000174214
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENSMUST00000018744 3.531±0.57 13.576±5.35 4.516±0.26 4.018±1.28 4.156±0.22 8.832±0.56 1.507±0.22 28.666±8.07 43.736±18.03 2.840±0.46 6.599±0.88 10.973±5.19 4.751±1.21
ENSMUST00000173260 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.555±1.78
ENSMUST00000174093 N/A N/A N/A N/A N/A N/A N/A 17.028±0.74 50.379±11.14 N/A N/A 9.478±0.00 6.094±0.32
ENSMUST00000174214 N/A N/A N/A N/A N/A N/A N/A N/A 58.496±16.05 N/A 8.227±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00002B CIL_00002B_0003 CGP 11:60740058-60788287
CIL_00058O CIL_00058O_0003 CGP 11:60777524-60811718

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004372 IEA glycine hydroxymethyltransferase activity
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 IEA cytosol
GO:0006545 IEA glycine biosynthetic process
GO:0006565 IEA L-serine catabolic process
GO:0008732 IEA L-allo-threonine aldolase activity
GO:0009113 IEA purine nucleobase biosynthetic process
GO:0016597 IEA amino acid binding
GO:0019264 IEA glycine biosynthetic process from serine
GO:0030170 IEA pyridoxal phosphate binding
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042802 IEA identical protein binding
GO:0042803 IEA protein homodimerization activity
GO:0046655 IEA folic acid metabolic process
GO:0051262 IEA protein tetramerization
GO:0051289 IEA protein homotetramerization
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052816 shmt1 serine hydroxymethyltransferase 1 (soluble) protein_coding Danio_rerio
ENSG00000176974 SHMT1 serine hydroxymethyltransferase 1 (soluble) protein_coding Homo_sapiens

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