C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine hydroxymethyltransferase 1 (soluble)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000176974 SHMT1 9606 - 17:18327860-18363563 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316694 SHMT1-001 18327873-18363487 protein_coding
  ENST00000352886 SHMT1-201 18327860-18363563 protein_coding
  ENST00000354098 SHMT1-003 18328528-18363451 protein_coding
  ENST00000395682 SHMT1-005 18353510-18363518 retained_intron
  ENST00000395684 SHMT1-004 18327873-18341655 retained_intron
  ENST00000579558 SHMT1-008 18340405-18363501 retained_intron
  ENST00000580002 SHMT1-006 18328470-18363495 nonsense_mediated_decay
  ENST00000582352 SHMT1-010 18330684-18333439 retained_intron
  ENST00000582653 SHMT1-009 18347514-18363346 protein_coding
  ENST00000583780 SHMT1-007 18355979-18363542 protein_coding
  ENST00000618902 SHMT1-202 18348244-18348672 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316694ENST00000352886ENST00000354098ENST00000395684ENST00000580002
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316694 19.998±0.00 6.290±0.00 N/A 3.703±0.00 11.084±9.44 3.209±1.96 2.030±1.54 57.918±46.52 66.150±65.30 5.102±0.00 5.777±0.00 6.890±2.18 6.543±1.96 8.815±0.00
ENST00000352886 N/A N/A 5.496±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000354098 N/A N/A 11.980±0.00 N/A N/A N/A N/A 18.516±0.00 1.745±0.00 N/A N/A 5.589±2.13 4.804±0.46 7.599±0.97
ENST00000395684 N/A N/A 8.230±0.00 1.944±0.00 N/A N/A N/A N/A N/A 2.579±0.00 N/A N/A N/A N/A
ENST00000580002 N/A N/A N/A N/A N/A 3.097±0.00 N/A 14.784±0.00 N/A N/A N/A N/A N/A 7.733±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00058O CIL_00058O_0002 CGP 17:18315310-18363563

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004372 IDA:IEA glycine hydroxymethyltransferase activity
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 IDA cytosol
GO:0006508 IEA proteolysis
GO:0006544 IEA glycine metabolic process
GO:0006545 IEA glycine biosynthetic process
GO:0006563 IEA L-serine metabolic process
GO:0006565 IDA L-serine catabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0008242 IEA omega peptidase activity
GO:0008732 IEA L-allo-threonine aldolase activity
GO:0009058 IEA biosynthetic process
GO:0009113 IDA purine nucleobase biosynthetic process
GO:0016597 IEA amino acid binding
GO:0019264 IEA glycine biosynthetic process from serine
GO:0030170 IEA:IDA pyridoxal phosphate binding
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042802 IEA identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0044281 TAS small molecule metabolic process
GO:0045329 TAS carnitine biosynthetic process
GO:0046655 IDA folic acid metabolic process
GO:0051262 IDA protein tetramerization
GO:0051289 IEA protein homotetramerization
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052816 shmt1 serine hydroxymethyltransferase 1 (soluble) protein_coding Danio_rerio
ENSMUSG00000020534 Shmt1 serine hydroxymethyltransferase 1 (soluble) protein_coding Mus_musculus

Loading