C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: metadherin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022255 Mtdh 10090 + 15:34082694-34142386 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022865 Mtdh-001 34082719-34142386 protein_coding
  ENSMUST00000163333 Mtdh-005 34083308-34136780 protein_coding
  ENSMUST00000163697 Mtdh-003 34082725-34124352 retained_intron
  ENSMUST00000168991 Mtdh-010 34083036-34134344 nonsense_mediated_decay
  ENSMUST00000169905 Mtdh-006 34114942-34140710 protein_coding
  ENSMUST00000170050 Mtdh-008 34083319-34136811 protein_coding
  ENSMUST00000170553 Mtdh-009 34083322-34123750 protein_coding
  ENSMUST00000171711 Mtdh-004 34133490-34141283 processed_transcript
  ENSMUST00000172082 Mtdh-002 34082694-34103345 retained_intron
  ENSMUST00000172083 Mtdh-007 34083853-34117997 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022865ENSMUST00000163333ENSMUST00000163697ENSMUST00000168991ENSMUST00000169905ENSMUST00000170050ENSMUST00000170553ENSMUST00000171711ENSMUST00000172082
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022865 8.528±3.11 9.434±5.35 18.656±1.48 11.695±0.50 14.475±6.49 12.429±2.91 4.488±0.00 4.272±1.98 8.097±3.86 10.443±3.60 15.052±4.85 5.820±1.75 11.760±5.89 13.849±1.39
ENSMUST00000163333 N/A N/A N/A 9.160±0.00 N/A N/A N/A N/A N/A N/A N/A 12.385±0.00 12.247±0.00 42.115±0.00
ENSMUST00000163697 N/A N/A N/A 2.472±0.04 N/A N/A N/A N/A 1.045±0.00 N/A N/A 2.614±0.43 N/A N/A
ENSMUST00000168991 N/A N/A N/A N/A 8.492±0.00 N/A N/A N/A N/A N/A N/A 18.211±0.00 25.704±1.38 25.029±0.00
ENSMUST00000169905 N/A N/A N/A N/A 5.580±0.00 N/A 4.556±0.00 N/A N/A N/A N/A N/A N/A 18.087±1.37
ENSMUST00000170050 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 26.179±0.00 N/A N/A
ENSMUST00000170553 N/A N/A N/A 22.604±0.00 N/A N/A N/A N/A N/A N/A N/A 22.473±0.00 29.698±3.08 41.271±0.00
ENSMUST00000171711 N/A N/A N/A 13.620±0.00 N/A N/A N/A N/A N/A N/A N/A 16.972±0.00 22.031±6.76 20.089±8.17
ENSMUST00000172082 N/A 4.846±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001L2 CIL_0001L2_0002 CGP 15:33683876-34142386
CIL_0001KW CIL_0001KW_0002 CGP 15:34082694-34284295

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001085 IEA RNA polymerase II transcription factor binding
GO:0003713 IEA transcription coactivator activity
GO:0003725 ISO double-stranded RNA binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IEA cytoplasm
GO:0005783 ISS endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0005923 IEA tight junction
GO:0010508 IEA positive regulation of autophagy
GO:0016021 IEA integral component of membrane
GO:0016324 IEA apical plasma membrane
GO:0016604 IEA nuclear body
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0043066 IEA negative regulation of apoptotic process
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044822 IEA poly(A) RNA binding
GO:0045766 IEA positive regulation of angiogenesis
GO:0046581 IEA intercellular canaliculus
GO:0048471 ISS perinuclear region of cytoplasm
GO:0051059 ISS NF-kappaB binding
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070830 IEA tight junction assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004939 mtdhb metadherin b protein_coding Danio_rerio
ENSDARG00000014159 mtdha metadherin a protein_coding Danio_rerio
ENSG00000147649 MTDH metadherin protein_coding Homo_sapiens

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