C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: vascular endothelial growth factor A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000023951 Vegfa 10090 - 17:46016993-46032377 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024747 Vegfa-008 46016993-46031815 protein_coding
  ENSMUST00000071648 Vegfa-001 46016993-46032369 protein_coding
  ENSMUST00000113519 Vegfa-009 46018858-46031356 protein_coding
  ENSMUST00000113520 Vegfa-010 46018831-46031356 protein_coding
  ENSMUST00000133605 Vegfa-004 46018606-46024881 retained_intron
  ENSMUST00000142321 Vegfa-005 46018833-46024802 retained_intron
  ENSMUST00000142351 Vegfa-003 46018543-46032369 protein_coding
  ENSMUST00000143985 Vegfa-006 46018712-46021372 retained_intron
  ENSMUST00000146149 Vegfa-002 46025196-46031356 retained_intron
  ENSMUST00000150327 Vegfa-007 46018479-46024864 retained_intron
  ENSMUST00000167860 Vegfa-201 46016996-46032377 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000024747ENSMUST00000071648ENSMUST00000113519ENSMUST00000113520ENSMUST00000133605ENSMUST00000142351ENSMUST00000150327ENSMUST00000167860
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000024747 28.431±3.07 84.070±19.91 11.870±3.77 9.139±1.61 45.529±7.55 14.881±2.73 19.702±0.00 22.241±4.41 9.912±2.27 168.118±19.50 N/A 21.395±5.61 6.653±0.00 1.490±0.54
ENSMUST00000071648 18.042±3.96 59.481±28.46 16.509±4.82 19.225±5.45 15.337±2.48 16.681±2.58 26.629±6.43 17.426±4.37 15.012±7.20 87.723±16.13 24.305±2.04 22.007±7.28 12.379±8.12 0.724±0.14
ENSMUST00000113519 83.830±0.00 N/A N/A N/A 99.603±0.00 N/A N/A N/A N/A N/A N/A N/A 53.862±0.00 2.757±0.00
ENSMUST00000113520 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 63.503±0.41 N/A N/A
ENSMUST00000133605 N/A N/A N/A 25.358±0.00 N/A N/A N/A N/A 13.983±0.00 N/A N/A N/A N/A N/A
ENSMUST00000142351 32.075±5.62 87.960±28.06 N/A N/A 27.943±2.15 9.259±2.13 N/A 22.612±0.53 4.921±0.00 N/A 20.361±2.97 18.761±3.72 15.958±11.84 1.108±0.00
ENSMUST00000150327 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 49.401±0.00 N/A 0.914±0.00
ENSMUST00000167860 N/A N/A N/A 19.865±0.00 N/A N/A N/A N/A N/A N/A N/A 40.770±0.00 23.415±13.04 0.829±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YI CIL_0008YI_0002 VISTA 17:45708824-46310190
CIL_00049T CIL_00049T_0002 CGP 17:46016993-46128910

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IDA angiogenesis
GO:0001541 IMP ovarian follicle development
GO:0001568 IMP blood vessel development
GO:0001569 IMP patterning of blood vessels
GO:0001666 ISS response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001822 IMP kidney development
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001938 ISO positive regulation of endothelial cell proliferation
GO:0001944 IMP vasculature development
GO:0001968 ISS fibronectin binding
GO:0002040 IDA sprouting angiogenesis
GO:0002042 ISS cell migration involved in sprouting angiogenesis
GO:0002052 IGI positive regulation of neuroblast proliferation
GO:0002053 IDA positive regulation of mesenchymal cell proliferation
GO:0002092 ISS positive regulation of receptor internalization
GO:0002575 IEA basophil chemotaxis
GO:0003007 IMP heart morphogenesis
GO:0003151 IMP outflow tract morphogenesis
GO:0003169 IMP coronary vein morphogenesis
GO:0005102 IDA receptor binding
GO:0005125 ISS cytokine activity
GO:0005161 ISS platelet-derived growth factor receptor binding
GO:0005172 ISS vascular endothelial growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005615 IDA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007498 IMP mesoderm development
GO:0007595 IMP lactation
GO:0008083 ISS growth factor activity
GO:0008201 ISS heparin binding
GO:0008283 IMP cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008360 ISS regulation of cell shape
GO:0009986 ISS cell surface
GO:0010595 ISS positive regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016477 IDA cell migration
GO:0022408 IGI negative regulation of cell-cell adhesion
GO:0030141 ISS secretory granule
GO:0030224 ISS monocyte differentiation
GO:0030225 ISS macrophage differentiation
GO:0030324 IMP lung development
GO:0030335 IEA positive regulation of cell migration
GO:0030823 ISO regulation of cGMP metabolic process
GO:0030855 IMP epithelial cell differentiation
GO:0030949 ISS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 IMP post-embryonic camera-type eye development
GO:0031334 ISS positive regulation of protein complex assembly
GO:0031954 ISS positive regulation of protein autophosphorylation
GO:0032147 ISS activation of protein kinase activity
GO:0032793 ISS positive regulation of CREB transcription factor activity
GO:0033138 ISS positive regulation of peptidyl-serine phosphorylation
GO:0035148 ISS tube formation
GO:0035767 ISS endothelial cell chemotaxis
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0036303 IMP lymph vessel morphogenesis
GO:0038033 ISS positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA vascular endothelial growth factor signaling pathway
GO:0038091 ISS positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 IMP VEGF-activated neuropilin signaling pathway
GO:0038191 IEA neuropilin binding
GO:0040007 IMP growth
GO:0042056 ISS chemoattractant activity
GO:0042462 IMP eye photoreceptor cell development
GO:0042802 IEA identical protein binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0043117 IDA positive regulation of vascular permeability
GO:0043129 IMP surfactant homeostasis
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 ISS vascular endothelial growth factor receptor 1 binding
GO:0043184 ISS vascular endothelial growth factor receptor 2 binding
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043536 ISS positive regulation of blood vessel endothelial cell migration
GO:0045766 ISS positive regulation of angiogenesis
GO:0045785 ISS positive regulation of cell adhesion
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046982 ISO protein heterodimerization activity
GO:0048010 IDA vascular endothelial growth factor receptor signaling pathway
GO:0048018 ISS receptor agonist activity
GO:0048469 IMP cell maturation
GO:0048514 IDA blood vessel morphogenesis
GO:0048593 IMP camera-type eye morphogenesis
GO:0048666 IMP neuron development
GO:0048739 IMP cardiac muscle fiber development
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0048842 IDA positive regulation of axon extension involved in axon guidance
GO:0048844 IMP artery morphogenesis
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 IDA extracellular matrix binding
GO:0050918 IDA positive chemotaxis
GO:0050927 ISS positive regulation of positive chemotaxis
GO:0051272 ISS positive regulation of cellular component movement
GO:0051781 IEA positive regulation of cell division
GO:0051894 ISS positive regulation of focal adhesion assembly
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060319 IMP primitive erythrocyte differentiation
GO:0060426 IDA lung vasculature development
GO:0060749 IMP mammary gland alveolus development
GO:0060754 IEA positive regulation of mast cell chemotaxis
GO:0060948 IMP cardiac vascular smooth muscle cell development
GO:0060982 IMP coronary artery morphogenesis
GO:0061419 IEA positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071456 ISS cellular response to hypoxia
GO:0071542 IGI dopaminergic neuron differentiation
GO:0071679 IDA commissural neuron axon guidance
GO:0090037 ISS positive regulation of protein kinase C signaling
GO:0090050 ISS positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 IDA positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 IDA regulation of retinal ganglion cell axon guidance
GO:1900086 ISS positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 IEA positive regulation of p38MAPK cascade
GO:1901492 IDA positive regulation of lymphangiogenesis
GO:1901727 IEA positive regulation of histone deacetylase activity
GO:1902336 IMP positive regulation of retinal ganglion cell axon guidance
GO:1902533 ISS positive regulation of intracellular signal transduction
GO:1902966 IEA positive regulation of protein localization to early endosome
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034700 vegfab vascular endothelial growth factor Ab protein_coding Danio_rerio
ENSDARG00000045971 vegfaa vascular endothelial growth factor Aa protein_coding Danio_rerio
ENSG00000112715 VEGFA vascular endothelial growth factor A protein_coding Homo_sapiens

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