C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: vascular endothelial growth factor A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000112715 VEGFA 9606 + 6:43770184-43786487 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000230480 VEGFA-009 43771992-43784935 protein_coding
  ENST00000324450 VEGFA-011 43770707-43784562 protein_coding
  ENST00000372055 VEGFA-004 43770707-43784609 protein_coding
  ENST00000372064 VEGFA-002 43770707-43786487 protein_coding
  ENST00000372067 VEGFA-001 43770213-43786487 protein_coding
  ENST00000372077 VEGFA-019 43770782-43786487 protein_coding
  ENST00000413642 VEGFA-012 43770707-43784589 protein_coding
  ENST00000417285 VEGFA-014 43770707-43784562 protein_coding
  ENST00000425836 VEGFA-003 43770707-43784949 protein_coding
  ENST00000457104 VEGFA-022 43771247-43784562 protein_coding
  ENST00000476772 VEGFA-005 43770184-43778764 retained_intron
  ENST00000480614 VEGFA-007 43773172-43786484 retained_intron
  ENST00000482630 VEGFA-013 43770707-43784658 protein_coding
  ENST00000493786 VEGFA-010 43778172-43784564 retained_intron
  ENST00000497139 VEGFA-008 43777720-43786439 retained_intron
  ENST00000512683 VEGFA-006 43771247-43777825 retained_intron
  ENST00000518538 VEGFA-017 43771153-43778937 retained_intron
  ENST00000518689 VEGFA-023 43771247-43784562 protein_coding
  ENST00000518824 VEGFA-024 43771247-43784658 protein_coding
  ENST00000519767 VEGFA-015 43770793-43784562 protein_coding
  ENST00000520265 VEGFA-016 43774353-43784562 protein_coding
  ENST00000520948 VEGFA-020 43771083-43784949 protein_coding
  ENST00000523125 VEGFA-025 43771247-43784562 protein_coding
  ENST00000523873 VEGFA-021 43771209-43784609 protein_coding
  ENST00000523950 VEGFA-018 43771209-43784902 protein_coding
  ENST00000611736 VEGFA-201 43770209-43786484 protein_coding
  ENST00000615393 VEGFA-202 43770209-43786484 protein_coding
  ENST00000617771 VEGFA-203 43770209-43786484 protein_coding
  ENST00000621747 VEGFA-204 43770209-43786484 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000230480ENST00000372064ENST00000372067ENST00000372077ENST00000457104ENST00000480614ENST00000493786ENST00000497139ENST00000520948ENST00000523950ENST00000615393ENST00000617771ENST00000621747
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000230480 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 79.414±0.00 N/A N/A
ENST00000372064 N/A N/A N/A N/A N/A N/A N/A 11.298±0.00 N/A N/A 4.269±0.00 N/A N/A N/A
ENST00000372067 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.535±0.00 N/A 5.475±0.00 N/A N/A
ENST00000372077 17.219±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 7.799±0.00 N/A 2.873±0.00 7.960±0.47 0.672±0.00
ENST00000457104 N/A N/A N/A N/A N/A N/A N/A 24.090±0.00 N/A 53.618±0.00 N/A N/A N/A N/A
ENST00000480614 N/A 1.420±0.00 3.165±0.00 0.250±0.09 2.873±0.00 1.027±0.11 1.192±0.00 0.917±0.00 4.576±0.00 2.845±0.23 1.367±0.00 2.415±0.01 N/A 0.388±0.16
ENST00000493786 N/A N/A N/A N/A N/A 9.841±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000497139 19.675±0.00 3.459±0.00 N/A N/A 5.500±0.00 3.431±0.00 4.394±0.00 10.190±0.00 6.561±0.00 10.642±0.00 4.066±0.00 28.361±35.69 N/A 1.513±0.71
ENST00000520948 N/A N/A N/A 3.726±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000523950 N/A N/A N/A 1.764±0.00 N/A N/A N/A N/A N/A N/A N/A 10.875±0.00 12.871±0.00 N/A
ENST00000615393 N/A 3.289±0.00 5.275±0.00 N/A 5.621±0.00 4.102±2.06 N/A 1.692±0.00 7.920±0.00 N/A 8.047±0.00 14.750±15.11 6.381±1.82 1.336±0.67
ENST00000617771 N/A 2.754±0.00 N/A 2.636±0.00 N/A 2.074±0.00 N/A N/A N/A 10.207±0.00 N/A N/A N/A N/A
ENST00000621747 16.399±0.00 N/A 6.798±0.00 1.532±0.00 N/A N/A 5.996±2.49 2.495±0.00 N/A N/A 9.322±0.66 5.602±0.74 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YI CIL_0008YI_0001 VISTA 6:43493027-44094540

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IDA angiogenesis
GO:0001541 ISS ovarian follicle development
GO:0001568 IEA blood vessel development
GO:0001569 ISS patterning of blood vessels
GO:0001570 TAS vasculogenesis
GO:0001666 IDA response to hypoxia
GO:0001701 ISS in utero embryonic development
GO:0001822 ISS kidney development
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 ISS positive regulation of endothelial cell proliferation
GO:0001944 IEA vasculature development
GO:0001968 IDA fibronectin binding
GO:0002040 IEA sprouting angiogenesis
GO:0002042 IDA cell migration involved in sprouting angiogenesis
GO:0002052 ISS positive regulation of neuroblast proliferation
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002092 IDA positive regulation of receptor internalization
GO:0002575 IDA basophil chemotaxis
GO:0002576 TAS platelet degranulation
GO:0002687 TAS positive regulation of leukocyte migration
GO:0003007 ISS heart morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003169 ISS coronary vein morphogenesis
GO:0005102 IEA receptor binding
GO:0005125 ISS cytokine activity
GO:0005161 IPI platelet-derived growth factor receptor binding
GO:0005172 IPI vascular endothelial growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 NAS proteinaceous extracellular matrix
GO:0005615 ISS extracellular space
GO:0005737 IDA cytoplasm
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0007399 TAS nervous system development
GO:0007498 ISS mesoderm development
GO:0007595 ISS lactation
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008201 IEA heparin binding
GO:0008283 IEA cell proliferation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008360 IDA regulation of cell shape
GO:0009986 IDA cell surface
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010628 IDA positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016477 IEA cell migration
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0030141 IDA secretory granule
GO:0030168 TAS platelet activation
GO:0030224 IDA monocyte differentiation
GO:0030225 IDA macrophage differentiation
GO:0030324 ISS lung development
GO:0030335 IDA positive regulation of cell migration
GO:0030855 ISS epithelial cell differentiation
GO:0030949 IDA positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077 ISS post-embryonic camera-type eye development
GO:0031093 TAS platelet alpha granule lumen
GO:0031334 IDA positive regulation of protein complex assembly
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032147 IDA activation of protein kinase activity
GO:0032793 IDA positive regulation of CREB transcription factor activity
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0035148 IDA tube formation
GO:0035767 IDA endothelial cell chemotaxis
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0036303 ISS lymph vessel morphogenesis
GO:0038033 IDA positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038084 IDA vascular endothelial growth factor signaling pathway
GO:0038091 IDA positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190 ISS VEGF-activated neuropilin signaling pathway
GO:0038191 IPI neuropilin binding
GO:0040007 ISS growth
GO:0042056 IDA chemoattractant activity
GO:0042462 ISS eye photoreceptor cell development
GO:0042802 IPI identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043117 IDA positive regulation of vascular permeability
GO:0043129 ISS surfactant homeostasis
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043183 IPI vascular endothelial growth factor receptor 1 binding
GO:0043184 IPI vascular endothelial growth factor receptor 2 binding
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0045766 IMP positive regulation of angiogenesis
GO:0045785 IDA positive regulation of cell adhesion
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IDA protein heterodimerization activity
GO:0048010 IDA vascular endothelial growth factor receptor signaling pathway
GO:0048018 IPI receptor agonist activity
GO:0048469 ISS cell maturation
GO:0048514 IEA blood vessel morphogenesis
GO:0048593 ISS camera-type eye morphogenesis
GO:0048666 IEA neuron development
GO:0048739 ISS cardiac muscle fiber development
GO:0048754 ISS branching morphogenesis of an epithelial tube
GO:0048842 ISS positive regulation of axon extension involved in axon guidance
GO:0048844 ISS artery morphogenesis
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050840 IC extracellular matrix binding
GO:0050918 IDA positive chemotaxis
GO:0050927 IDA positive regulation of positive chemotaxis
GO:0050930 NAS induction of positive chemotaxis
GO:0051272 IDA positive regulation of cellular component movement
GO:0051781 IEA positive regulation of cell division
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060319 ISS primitive erythrocyte differentiation
GO:0060426 IEA lung vasculature development
GO:0060749 ISS mammary gland alveolus development
GO:0060754 IDA positive regulation of mast cell chemotaxis
GO:0060948 ISS cardiac vascular smooth muscle cell development
GO:0060982 ISS coronary artery morphogenesis
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419 IMP positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071456 IDA cellular response to hypoxia
GO:0071542 ISS dopaminergic neuron differentiation
GO:0071679 ISS commissural neuron axon guidance
GO:0090037 IDA positive regulation of protein kinase C signaling
GO:0090050 IDA positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259 ISS regulation of retinal ganglion cell axon guidance
GO:1900086 IDA positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745 IDA positive regulation of p38MAPK cascade
GO:1901492 IEA positive regulation of lymphangiogenesis
GO:1901727 IDA positive regulation of histone deacetylase activity
GO:1902336 ISS positive regulation of retinal ganglion cell axon guidance
GO:1902533 IDA positive regulation of intracellular signal transduction
GO:1902966 IDA positive regulation of protein localization to early endosome
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034700 vegfab vascular endothelial growth factor Ab protein_coding Danio_rerio
ENSDARG00000045971 vegfaa vascular endothelial growth factor Aa protein_coding Danio_rerio
ENSMUSG00000023951 Vegfa vascular endothelial growth factor A protein_coding Mus_musculus

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