C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026177 Slc11a1 10090 + 1:74375195-74386062 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027368 Slc11a1-001 74375203-74386062 protein_coding
  ENSMUST00000127487 Slc11a1-008 74383034-74383834 retained_intron
  ENSMUST00000131511 Slc11a1-003 74375225-74386051 retained_intron
  ENSMUST00000133896 Slc11a1-007 74381651-74384173 retained_intron
  ENSMUST00000134189 Slc11a1-010 74383600-74385197 processed_transcript
  ENSMUST00000135137 Slc11a1-005 74375572-74376890 processed_transcript
  ENSMUST00000136786 Slc11a1-004 74375253-74381826 processed_transcript
  ENSMUST00000147233 Slc11a1-002 74375203-74386052 retained_intron
  ENSMUST00000149166 Slc11a1-009 74383341-74384173 processed_transcript
  ENSMUST00000155865 Slc11a1-006 74376657-74379856 processed_transcript
  ENSMUST00000187516 Slc11a1-011 74375195-74385755 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027368ENSMUST00000127487ENSMUST00000131511ENSMUST00000133896ENSMUST00000134189ENSMUST00000136786ENSMUST00000147233ENSMUST00000149166ENSMUST00000187516
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027368 5.390±1.00 7.979±1.57 3.117±0.20 0.357±0.13 8.493±2.44 2.502±0.55 0.941±0.39 0.623±0.23 4.310±2.49 3.958±0.61 0.438±0.17 4.174±1.71 0.870±1.06 0.359±0.01
ENSMUST00000127487 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.137±0.06 N/A
ENSMUST00000131511 N/A N/A N/A N/A N/A N/A 0.348±0.00 N/A N/A N/A N/A N/A 0.200±0.00 N/A
ENSMUST00000133896 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.192±0.00
ENSMUST00000134189 18.566±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.828±0.00 N/A 0.471±0.00 N/A
ENSMUST00000136786 N/A N/A N/A 0.271±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.284±0.00
ENSMUST00000147233 2.965±0.96 N/A 1.163±0.06 N/A 3.474±0.32 1.093±0.20 0.530±0.04 0.442±0.00 1.899±0.59 1.496±0.39 0.107±0.00 1.529±0.48 0.239±0.00 0.321±0.26
ENSMUST00000149166 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.577±0.00
ENSMUST00000187516 5.278±0.80 4.653±1.56 N/A 0.314±0.00 7.964±1.90 2.070±0.22 1.137±0.58 1.008±0.33 2.435±0.97 3.026±0.93 0.117±0.00 3.975±1.21 0.033±0.00 0.297±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00054V CIL_00054V_0002 CGP 1:74362108-74386062
CIL_0005VF CIL_0005VF_0002 CGP 1:74375195-74397285

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IMP protein import into nucleus, translocation
GO:0000165 ISO MAPK cascade
GO:0001818 IMP negative regulation of cytokine production
GO:0001819 IMP positive regulation of cytokine production
GO:0002309 IMP T cell proliferation involved in immune response
GO:0002369 IMP T cell cytokine production
GO:0002606 IMP positive regulation of dendritic cell antigen processing and presentation
GO:0002827 IMP positive regulation of T-helper 1 type immune response
GO:0005384 IMP manganese ion transmembrane transporter activity
GO:0005764 IDA lysosome
GO:0005770 IDA late endosome
GO:0005886 IEA plasma membrane
GO:0006826 IMP iron ion transport
GO:0006828 IMP manganese ion transport
GO:0006876 IEA cellular cadmium ion homeostasis
GO:0006879 IMP cellular iron ion homeostasis
GO:0006909 IMP phagocytosis
GO:0006954 IMP inflammatory response
GO:0007035 IMP vacuolar acidification
GO:0009279 IDA cell outer membrane
GO:0009617 IMP response to bacterium
GO:0010008 IDA endosome membrane
GO:0010628 IMP positive regulation of gene expression
GO:0015707 IDA nitrite transport
GO:0016021 IEA integral component of membrane
GO:0030670 IDA phagocytic vesicle membrane
GO:0032147 IMP activation of protein kinase activity
GO:0032496 ISO response to lipopolysaccharide
GO:0032623 IMP interleukin-2 production
GO:0032632 IMP interleukin-3 production
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0034341 IDA response to interferon-gamma
GO:0042060 IMP wound healing
GO:0042116 IMP macrophage activation
GO:0042742 IMP defense response to bacterium
GO:0042803 IEA protein homodimerization activity
GO:0042832 IMP defense response to protozoan
GO:0043091 IDA L-arginine import
GO:0045342 IMP MHC class II biosynthetic process
GO:0045730 IDA respiratory burst
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046915 IEA transition metal ion transmembrane transporter activity
GO:0048002 IMP antigen processing and presentation of peptide antigen
GO:0048255 IMP mRNA stabilization
GO:0050766 IMP positive regulation of phagocytosis
GO:0050829 IMP defense response to Gram-negative bacterium
GO:0051139 IEA metal ion:proton antiporter activity
GO:0055072 IMP iron ion homeostasis
GO:0060586 IMP multicellular organismal iron ion homeostasis
GO:0070574 IEA cadmium ion transmembrane transport
GO:0070821 IEA tertiary granule membrane
GO:0070839 IDA divalent metal ion export
GO:0071421 IMP manganese ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000018280 SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 protein_coding Homo_sapiens

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