C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000018280 SLC11A1 9606 + 2:218382029-218396894 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000233202 SLC11A1-001 218382029-218396894 protein_coding
  ENST00000354352 SLC11A1-003 218382248-218395323 nonsense_mediated_decay
  ENST00000460592 SLC11A1-018 218385155-218385574 retained_intron
  ENST00000465984 SLC11A1-004 218382188-218396026 retained_intron
  ENST00000468221 SLC11A1-009 218382029-218396027 retained_intron
  ENST00000468721 SLC11A1-005 218392840-218394186 retained_intron
  ENST00000469449 SLC11A1-011 218383687-218388385 retained_intron
  ENST00000469799 SLC11A1-016 218382279-218387112 retained_intron
  ENST00000471875 SLC11A1-015 218382279-218386772 retained_intron
  ENST00000473367 SLC11A1-013 218382169-218386667 nonsense_mediated_decay
  ENST00000475225 SLC11A1-002 218382302-218388385 retained_intron
  ENST00000481524 SLC11A1-014 218382273-218387584 nonsense_mediated_decay
  ENST00000483487 SLC11A1-017 218384167-218386813 retained_intron
  ENST00000490536 SLC11A1-012 218392590-218394635 retained_intron
  ENST00000490872 SLC11A1-019 218389965-218391771 retained_intron
  ENST00000492413 SLC11A1-006 218382287-218387134 retained_intron
  ENST00000494322 SLC11A1-010 218382273-218392635 retained_intron
  ENST00000539932 SLC11A1-007 218382203-218392692 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000233202ENST00000354352ENST00000468221ENST00000469449ENST00000473367ENST00000475225ENST00000483487ENST00000490536ENST00000490872ENST00000494322ENST00000539932
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000233202 N/A 0.823±0.00 N/A 0.028±0.00 0.266±0.00 0.233±0.20 0.017±0.00 N/A 0.874±0.00 N/A 0.092±0.00 0.426±0.00 N/A 0.517±0.00
ENST00000354352 7.010±0.00 N/A N/A N/A 0.558±0.00 N/A N/A 1.756±0.00 0.641±0.00 15.428±9.37 N/A 1.049±0.00 5.559±2.76 N/A
ENST00000468221 N/A 0.456±0.00 N/A 1.601±0.00 0.301±0.00 N/A N/A N/A 0.186±0.00 N/A N/A 0.270±0.11 0.176±0.00 N/A
ENST00000469449 N/A N/A 0.066±0.00 N/A N/A N/A N/A N/A N/A N/A 0.159±0.00 0.247±0.00 N/A N/A
ENST00000473367 N/A N/A N/A 0.048±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000475225 N/A 1.306±0.00 N/A N/A N/A 0.133±0.00 N/A N/A 0.241±0.00 N/A N/A N/A N/A 0.299±0.00
ENST00000483487 N/A N/A N/A N/A N/A N/A 0.128±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000490536 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.525±0.00 N/A N/A
ENST00000490872 N/A N/A N/A N/A N/A 1.384±0.00 N/A N/A 0.760±0.00 N/A N/A N/A N/A N/A
ENST00000494322 N/A N/A 0.022±0.00 N/A N/A N/A 0.558±0.43 N/A 0.683±0.00 N/A N/A 0.228±0.00 N/A N/A
ENST00000539932 N/A N/A 0.027±0.00 0.078±0.00 N/A N/A N/A N/A N/A N/A 0.153±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00054V CIL_00054V_0001 CGP 2:218356856-218396894
CIL_0005VF CIL_0005VF_0001 CGP 2:218382029-218405941

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IEA protein import into nucleus, translocation
GO:0001818 ISS negative regulation of cytokine production
GO:0001819 ISS positive regulation of cytokine production
GO:0002309 ISS T cell proliferation involved in immune response
GO:0002369 ISS T cell cytokine production
GO:0002606 ISS positive regulation of dendritic cell antigen processing and presentation
GO:0002827 ISS positive regulation of T-helper 1 type immune response
GO:0003674 ND molecular_function
GO:0005215 IEA transporter activity
GO:0005384 ISS manganese ion transmembrane transporter activity
GO:0005575 ND cellular_component
GO:0005764 ISS lysosome
GO:0005770 ISS late endosome
GO:0005886 IMP plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0006810 IEA transport
GO:0006826 IMP iron ion transport
GO:0006828 ISS manganese ion transport
GO:0006876 IGI cellular cadmium ion homeostasis
GO:0006879 IMP cellular iron ion homeostasis
GO:0006909 ISS phagocytosis
GO:0006954 ISS inflammatory response
GO:0006955 NAS immune response
GO:0007035 ISS vacuolar acidification
GO:0009279 IEA cell outer membrane
GO:0009617 IDA response to bacterium
GO:0010008 IEA endosome membrane
GO:0010628 ISS positive regulation of gene expression
GO:0015707 ISS nitrite transport
GO:0016020 IEA membrane
GO:0030670 IDA phagocytic vesicle membrane
GO:0031902 TAS late endosome membrane
GO:0032147 ISS activation of protein kinase activity
GO:0032496 ISS response to lipopolysaccharide
GO:0032623 ISS interleukin-2 production
GO:0032632 ISS interleukin-3 production
GO:0032729 ISS positive regulation of interferon-gamma production
GO:0034341 ISS response to interferon-gamma
GO:0042060 ISS wound healing
GO:0042116 ISS macrophage activation
GO:0042742 ISS defense response to bacterium
GO:0042803 IDA protein homodimerization activity
GO:0042832 ISS defense response to protozoan
GO:0043091 ISS L-arginine import
GO:0045342 ISS MHC class II biosynthetic process
GO:0045730 ISS respiratory burst
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046915 IGI transition metal ion transmembrane transporter activity
GO:0048002 ISS antigen processing and presentation of peptide antigen
GO:0048255 ISS mRNA stabilization
GO:0050766 ISS positive regulation of phagocytosis
GO:0050829 ISS defense response to Gram-negative bacterium
GO:0051139 IGI metal ion:proton antiporter activity
GO:0051701 TAS interaction with host
GO:0055072 ISS iron ion homeostasis
GO:0055085 TAS transmembrane transport
GO:0060586 ISS multicellular organismal iron ion homeostasis
GO:0070574 IGI cadmium ion transmembrane transport
GO:0070821 IDA tertiary granule membrane
GO:0070839 ISS divalent metal ion export
GO:0071421 IEA manganese ion transmembrane transport
GO:0090382 TAS phagosome maturation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000026177 Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 protein_coding Mus_musculus

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