C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TRAF2 and NCK interacting kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027692 Tnik 10090 + 3:28263214-28675858 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000159236 Tnik-001 28263215-28675858 protein_coding
  ENSMUST00000159308 Tnik-011 28263643-28667982 protein_coding
  ENSMUST00000159680 Tnik-010 28263563-28668223 protein_coding
  ENSMUST00000159733 Tnik-006 28650027-28665945 retained_intron
  ENSMUST00000160307 Tnik-007 28263563-28668223 protein_coding
  ENSMUST00000160518 Tnik-008 28263643-28667982 protein_coding
  ENSMUST00000160934 Tnik-003 28263214-28670585 nonsense_mediated_decay
  ENSMUST00000161214 Tnik-005 28263276-28360786 retained_intron
  ENSMUST00000161234 Tnik-002 28263276-28494134 retained_intron
  ENSMUST00000161423 Tnik-004 28409431-28596083 processed_transcript
  ENSMUST00000161964 Tnik-014 28263643-28667982 protein_coding
  ENSMUST00000162037 Tnik-016 28263563-28666449 retained_intron
  ENSMUST00000162225 Tnik-015 28629872-28638469 retained_intron
  ENSMUST00000162485 Tnik-009 28263643-28667982 protein_coding
  ENSMUST00000162777 Tnik-013 28263643-28667982 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000159236ENSMUST00000159308ENSMUST00000159680ENSMUST00000160307ENSMUST00000160518ENSMUST00000160934ENSMUST00000161214ENSMUST00000161423ENSMUST00000161964ENSMUST00000162037ENSMUST00000162485ENSMUST00000162777
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000159236 0.184±0.08 0.256±0.05 1.126±0.63 1.072±0.00 0.692±0.21 0.325±0.09 1.169±0.00 0.053±0.03 0.067±0.05 0.614±0.31 0.659±0.00 0.257±0.07 0.083±0.02 0.354±0.00
ENSMUST00000159308 N/A N/A N/A N/A N/A N/A N/A N/A 0.054±0.00 N/A N/A N/A N/A N/A
ENSMUST00000159680 0.506±0.38 0.413±0.08 N/A N/A 1.167±0.06 0.575±0.18 1.090±0.33 N/A N/A 1.903±0.77 1.653±0.81 0.842±0.47 0.200±0.00 0.986±0.34
ENSMUST00000160307 N/A 1.241±0.00 N/A 6.924±4.12 N/A 0.782±0.00 0.959±0.30 0.109±0.00 0.121±0.04 N/A N/A 0.799±0.17 N/A N/A
ENSMUST00000160518 N/A 0.943±0.24 N/A N/A N/A 0.938±0.17 N/A 0.140±0.03 0.160±0.07 0.789±0.02 N/A 0.974±0.52 N/A N/A
ENSMUST00000160934 0.647±0.36 0.537±0.08 2.799±0.62 10.376±3.48 0.365±0.00 0.613±0.12 0.494±0.09 0.105±0.03 0.340±0.19 0.636±0.17 1.340±0.43 1.133±1.07 0.605±0.19 1.324±0.34
ENSMUST00000161214 N/A N/A N/A N/A N/A N/A N/A 0.181±0.00 N/A N/A N/A N/A N/A N/A
ENSMUST00000161423 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.616±0.00 1.150±0.44 12.816±0.00
ENSMUST00000161964 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.363±0.00 N/A N/A
ENSMUST00000162037 N/A N/A N/A N/A N/A 0.878±0.42 N/A 0.111±0.00 N/A N/A N/A N/A N/A N/A
ENSMUST00000162485 N/A N/A N/A 31.433±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.056±0.00
ENSMUST00000162777 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.213±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00070U CIL_00070U_0002 CGP 3:27938695-28675858
CIL_0007SJ CIL_0007SJ_0002 VISTA 3:28120093-28722161
CIL_00080K CIL_00080K_0002 VISTA 3:28128875-28733466
CIL_0008FL CIL_0008FL_0002 VISTA 3:28138282-28741962
CIL_000710 CIL_000710_0002 CGP 3:28263214-28728356

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005083 IEA small GTPase regulator activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005856 ISS cytoskeleton
GO:0006468 ISS protein phosphorylation
GO:0007010 IEA cytoskeleton organization
GO:0007256 ISS activation of JNKK activity
GO:0016055 IEA Wnt signaling pathway
GO:0031532 ISS actin cytoskeleton reorganization
GO:0035556 ISS intracellular signal transduction
GO:0046777 ISS protein autophosphorylation
GO:0048471 ISO perinuclear region of cytoplasm
GO:0048814 ISS regulation of dendrite morphogenesis
GO:0050790 IEA regulation of catalytic activity
GO:0055037 ISO recycling endosome
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009031 tnikb TRAF2 and NCK interacting kinase b protein_coding Danio_rerio
ENSDARG00000056218 tnika TRAF2 and NCK interacting kinase a protein_coding Danio_rerio
ENSG00000154310 TNIK TRAF2 and NCK interacting kinase protein_coding Homo_sapiens

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