C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lymphoid enhancer binding factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000029611 Lef1-001 ENSMUSG00000027985 10090 + 3:131110471-131224356 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENSMUST00000029611
Transcript ID Adipose Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENSMUST00000029611 1.475±1.66 0.938±0.18 4.277±2.46 0.545±0.17 0.059±0.02 0.395±0.25 0.206±0.27 1.090±0.37 0.141±0.09 0.433±0.20 0.169±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T5 CIL_0008T5_0002 VISTA 3:130661754-131264427
CIL_00097H CIL_00097H_0002 VISTA 3:130836337-131437858
CIL_0000FF CIL_0000FF_0002 CGP 3:131110471-131272101

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001569 IMP patterning of blood vessels
GO:0001649 IBA osteoblast differentiation
GO:0001755 IBA neural crest cell migration
GO:0001756 IGI somitogenesis
GO:0001837 IMP epithelial to mesenchymal transition
GO:0001944 IMP vasculature development
GO:0002040 IMP sprouting angiogenesis
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IGI RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IPI transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008013 IBA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008301 IDA DNA binding, bending
GO:0010628 IEA positive regulation of gene expression
GO:0010718 IEA positive regulation of epithelial to mesenchymal transition
GO:0016055 IGI Wnt signaling pathway
GO:0021542 IMP dentate gyrus development
GO:0021766 IMP hippocampus development
GO:0021854 IBA hypothalamus development
GO:0021861 IGI forebrain radial glial cell differentiation
GO:0021873 IGI forebrain neuroblast division
GO:0021879 IBA forebrain neuron differentiation
GO:0021943 IGI formation of radial glial scaffolds
GO:0022407 IMP regulation of cell-cell adhesion
GO:0022408 IEA negative regulation of cell-cell adhesion
GO:0022409 IEA positive regulation of cell-cell adhesion
GO:0030111 IGI regulation of Wnt signaling pathway
GO:0030223 IBA neutrophil differentiation
GO:0030284 IEA estrogen receptor activity
GO:0030307 IEA positive regulation of cell growth
GO:0030326 IGI embryonic limb morphogenesis
GO:0030331 IBA estrogen receptor binding
GO:0030335 IEA positive regulation of cell migration
GO:0030509 IDA BMP signaling pathway
GO:0030854 IEA positive regulation of granulocyte differentiation
GO:0030879 IMP mammary gland development
GO:0032696 IBA negative regulation of interleukin-13 production
GO:0032713 IBA negative regulation of interleukin-4 production
GO:0032714 IBA negative regulation of interleukin-5 production
GO:0032993 IEA protein-DNA complex
GO:0033153 IGI T cell receptor V(D)J recombination
GO:0035326 IBA enhancer binding
GO:0042100 IMP B cell proliferation
GO:0042393 IEA histone binding
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0043027 IEA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IBA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 IEA negative regulation of DNA binding
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IBA sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0043923 IEA positive regulation by host of viral transcription
GO:0043966 IEA histone H3 acetylation
GO:0043967 IEA histone H4 acetylation
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045063 IDA T-helper 1 cell differentiation
GO:0045295 IBA gamma-catenin binding
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046632 IGI alpha-beta T cell differentiation
GO:0048069 IBA eye pigmentation
GO:0048341 IGI paraxial mesoderm formation
GO:0048468 IGI cell development
GO:0048747 IBA muscle fiber development
GO:0050909 IMP sensory perception of taste
GO:0060021 IMP palate development
GO:0060033 IMP anatomical structure regression
GO:0060070 IBA canonical Wnt signaling pathway
GO:0060325 IGI face morphogenesis
GO:0060326 IEA cell chemotaxis
GO:0060561 IMP apoptotic process involved in morphogenesis
GO:0060710 IGI chorio-allantoic fusion
GO:0061153 IMP trachea gland development
GO:0070016 IBA armadillo repeat domain binding
GO:0070742 IEA C2H2 zinc finger domain binding
GO:0071345 IEA cellular response to cytokine stimulus
GO:0071353 IEA cellular response to interleukin-4
GO:0071864 IBA positive regulation of cell proliferation in bone marrow
GO:0071866 IBA negative regulation of apoptotic process in bone marrow
GO:0071895 IBA odontoblast differentiation
GO:0071899 IEA negative regulation of estrogen receptor binding
GO:0090068 IEA positive regulation of cell cycle process
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1902262 IMP apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000132405 lef1-001 protein_coding Danio_rerio 0 340
ENSDART00000047876 lef1-002 protein_coding Danio_rerio 0 265
ENST00000265165 LEF1-001 protein_coding Homo_sapiens 0 1965
ENST00000379951 LEF1-201 protein_coding Homo_sapiens 0 989
ENST00000438313 LEF1-020 protein_coding Homo_sapiens 0 931
ENST00000503879 LEF1-017 processed_transcript Homo_sapiens 0 547
ENST00000504426 LEF1-013 processed_transcript Homo_sapiens 0 512
ENST00000504775 LEF1-008 processed_transcript Homo_sapiens 0 604
ENST00000504950 LEF1-007 nonsense_mediated_decay Homo_sapiens 0 531
ENST00000505293 LEF1-002 processed_transcript Homo_sapiens 0 544
ENST00000505297 LEF1-011 processed_transcript Homo_sapiens 0 512
ENST00000505379 LEF1-010 processed_transcript Homo_sapiens 0 619
ENST00000506680 LEF1-019 nonsense_mediated_decay Homo_sapiens 0 1158
ENST00000507470 LEF1-016 retained_intron Homo_sapiens 0 499
ENST00000509428 LEF1-009 processed_transcript Homo_sapiens 0 859
ENST00000510135 LEF1-005 processed_transcript Homo_sapiens 0 931
ENST00000510624 LEF1-018 protein_coding Homo_sapiens 0 841
ENST00000510717 LEF1-004 processed_transcript Homo_sapiens 0 641
ENST00000512172 LEF1-006 protein_coding Homo_sapiens 0 564
ENST00000512407 LEF1-014 processed_transcript Homo_sapiens 0 422
ENST00000514444 LEF1-012 processed_transcript Homo_sapiens 0 512
ENST00000515500 LEF1-003 protein_coding Homo_sapiens 0 708

Loading