C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: lymphoid enhancer binding factor 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000098611 Lef1-002 ENSMUSG00000027985 10090 + 3:131112797-131224356 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000098611
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000098611 1.391±1.31 4.032±1.60 0.353±0.11 0.308±0.00 15.587±7.72 0.270±0.05 0.354±0.21 1.014±0.68 0.277±0.32 2.468±0.69 0.221±0.24 0.721±0.60 0.077±0.04 9.744±3.80

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008T5 CIL_0008T5_0002 VISTA 3:130661754-131264427
CIL_00097H CIL_00097H_0002 VISTA 3:130836337-131437858
CIL_0000FF CIL_0000FF_0002 CGP 3:131110471-131272101

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001569 IMP patterning of blood vessels
GO:0001649 IBA osteoblast differentiation
GO:0001755 IBA neural crest cell migration
GO:0001756 IGI somitogenesis
GO:0001944 IMP vasculature development
GO:0002040 IMP sprouting angiogenesis
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IGI RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IPI transcription factor complex
GO:0005737 IDA cytoplasm
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IGI transcription from RNA polymerase II promoter
GO:0008013 IBA beta-catenin binding
GO:0008134 IPI transcription factor binding
GO:0016055 IGI Wnt signaling pathway
GO:0021542 IMP dentate gyrus development
GO:0021766 IMP hippocampus development
GO:0021854 IBA hypothalamus development
GO:0021861 IGI forebrain radial glial cell differentiation
GO:0021873 IGI forebrain neuroblast division
GO:0021879 IBA forebrain neuron differentiation
GO:0021943 IGI formation of radial glial scaffolds
GO:0022407 IMP regulation of cell-cell adhesion
GO:0030111 IGI regulation of Wnt signaling pathway
GO:0030223 IBA neutrophil differentiation
GO:0030326 IGI embryonic limb morphogenesis
GO:0030331 IBA estrogen receptor binding
GO:0030509 IDA BMP signaling pathway
GO:0030879 IMP mammary gland development
GO:0032696 IBA negative regulation of interleukin-13 production
GO:0032713 IBA negative regulation of interleukin-4 production
GO:0032714 IBA negative regulation of interleukin-5 production
GO:0033153 IGI T cell receptor V(D)J recombination
GO:0035326 IBA enhancer binding
GO:0042100 IMP B cell proliferation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0043154 IBA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 IBA sequence-specific DNA binding
GO:0043586 IMP tongue development
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045295 IBA gamma-catenin binding
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046632 IGI alpha-beta T cell differentiation
GO:0048069 IBA eye pigmentation
GO:0048341 IGI paraxial mesoderm formation
GO:0048468 IGI cell development
GO:0048747 IBA muscle fiber development
GO:0050909 IMP sensory perception of taste
GO:0060033 IMP anatomical structure regression
GO:0060070 IBA canonical Wnt signaling pathway
GO:0060325 IGI face morphogenesis
GO:0060561 IMP apoptotic process involved in morphogenesis
GO:0060710 IGI chorio-allantoic fusion
GO:0061153 IMP trachea gland development
GO:0070016 IBA armadillo repeat domain binding
GO:0071864 IBA positive regulation of cell proliferation in bone marrow
GO:0071866 IBA negative regulation of apoptotic process in bone marrow
GO:0071895 IBA odontoblast differentiation
GO:1902262 IMP apoptotic process involved in patterning of blood vessels

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000132405 lef1-001 protein_coding Danio_rerio 0 340
ENSDART00000047876 lef1-002 protein_coding Danio_rerio 0 265
ENST00000265165 LEF1-001 protein_coding Homo_sapiens 0 1628
ENST00000379951 LEF1-201 protein_coding Homo_sapiens 0 619
ENST00000438313 LEF1-020 protein_coding Homo_sapiens 0 931
ENST00000503879 LEF1-017 processed_transcript Homo_sapiens 0 547
ENST00000504426 LEF1-013 processed_transcript Homo_sapiens 0 512
ENST00000504775 LEF1-008 processed_transcript Homo_sapiens 0 566
ENST00000504950 LEF1-007 nonsense_mediated_decay Homo_sapiens 0 531
ENST00000505293 LEF1-002 processed_transcript Homo_sapiens 0 544
ENST00000505297 LEF1-011 processed_transcript Homo_sapiens 0 512
ENST00000505379 LEF1-010 processed_transcript Homo_sapiens 0 619
ENST00000506680 LEF1-019 nonsense_mediated_decay Homo_sapiens 0 894
ENST00000507470 LEF1-016 retained_intron Homo_sapiens 0 499
ENST00000509428 LEF1-009 processed_transcript Homo_sapiens 0 859
ENST00000510135 LEF1-005 processed_transcript Homo_sapiens 0 931
ENST00000510624 LEF1-018 protein_coding Homo_sapiens 0 841
ENST00000510717 LEF1-004 processed_transcript Homo_sapiens 0 640
ENST00000512172 LEF1-006 protein_coding Homo_sapiens 0 582
ENST00000512407 LEF1-014 processed_transcript Homo_sapiens 0 422
ENST00000514444 LEF1-012 processed_transcript Homo_sapiens 0 512
ENST00000515500 LEF1-003 protein_coding Homo_sapiens 0 726

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