C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BRCA1/BRCA2-containing complex, subunit 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031201 Brcc3 10090 + X:75416628-75454001 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033544 Brcc3-001 75416628-75454001 protein_coding
  ENSMUST00000114074 Brcc3-004 75416710-75451708 protein_coding
  ENSMUST00000118428 Brcc3-008 75416697-75451985 protein_coding
  ENSMUST00000124321 Brcc3-005 75433978-75451224 retained_intron
  ENSMUST00000133781 Brcc3-007 75416716-75437991 protein_coding
  ENSMUST00000151938 Brcc3-003 75416700-75450732 retained_intron
  ENSMUST00000152228 Brcc3-006 75417307-75435475 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033544ENSMUST00000114074ENSMUST00000118428ENSMUST00000124321ENSMUST00000133781ENSMUST00000151938ENSMUST00000152228
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033544 1.537±0.29 1.600±1.11 2.628±0.03 3.272±1.60 1.226±0.61 0.932±0.46 1.162±0.18 2.211±0.42 3.649±1.62 2.408±0.35 1.652±0.22 1.322±0.77 0.972±0.54 0.304±0.17
ENSMUST00000114074 1.971±0.27 N/A 3.565±0.05 3.078±0.12 1.331±0.12 2.296±0.98 2.214±1.02 3.045±0.58 2.982±1.20 1.700±0.26 1.216±0.24 1.141±0.49 1.268±0.66 0.422±0.10
ENSMUST00000118428 N/A N/A N/A N/A 1.229±0.00 N/A N/A N/A 1.574±0.00 N/A N/A 0.307±0.00 N/A 0.232±0.13
ENSMUST00000124321 0.735±0.00 N/A 1.224±0.00 N/A 0.644±0.24 1.005±0.36 N/A N/A 1.316±0.00 N/A N/A 1.146±0.37 0.650±0.37 0.047±0.00
ENSMUST00000133781 N/A 1.596±0.07 N/A 19.388±0.00 4.937±1.78 2.040±0.54 5.223±0.10 N/A 3.962±0.00 N/A 7.558±0.63 14.858±0.00 17.394±12.63 0.904±0.09
ENSMUST00000151938 N/A 0.552±0.19 N/A N/A 0.434±0.04 0.568±0.19 N/A N/A N/A N/A N/A 0.933±0.27 0.343±0.00 0.095±0.06
ENSMUST00000152228 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.683±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003LJ CIL_0003LJ_0002 CGP X:75416628-75534942

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IEA ubiquitin ligase complex
GO:0000152 IEA nuclear ubiquitin ligase complex
GO:0004221 ISS ubiquitin thiolesterase activity
GO:0004843 ISS ubiquitin-specific protease activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0006302 ISS double-strand break repair
GO:0006508 IEA proteolysis
GO:0008237 ISS metallopeptidase activity
GO:0010165 IEA response to X-ray
GO:0010212 ISS response to ionizing radiation
GO:0030234 IEA enzyme regulator activity
GO:0031572 ISS G2 DNA damage checkpoint
GO:0031593 ISS polyubiquitin binding
GO:0045739 ISS positive regulation of DNA repair
GO:0046872 IEA metal ion binding
GO:0050790 IEA regulation of catalytic activity
GO:0070531 ISS BRCA1-A complex
GO:0070536 ISS protein K63-linked deubiquitination
GO:0070537 ISS histone H2A K63-linked deubiquitination
GO:0070552 ISS BRISC complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078456 brcc3 BRCA1/BRCA2-containing complex, subunit 3 protein_coding Danio_rerio
ENSG00000185515 BRCC3 BRCA1/BRCA2-containing complex, subunit 3 protein_coding Homo_sapiens

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